Male Pattern Baldness Study
Study Code:MB
Sample:81 DZ twin pairs and their brother(s) and parents
Start Date:Sep.2001
Contact:Anjali Henders
More Info:QIMR only

This project aims to identify genes influencing early onset Male Pattern Baldness (MPB). The aim is to identify specific chromosomal regions that have at least a moderate effect on MPB. These implicated loci will then be further investigated in order to identify the causative gene(s) influencing MPB. Twin subjects from the previous "Semi-Structures Assessment for the genetics of Alcoholism" ("OZ Twin 89 Interview": "SSAGA-OZ") will be targetted. Initially 81 DZ pairs and their families will be approached. These 81 twin pairs have been identified as concordant with hair loss from their Twin 89 interview questions.

The study will involve collecting phenotypic (hair loss) information from twins, male siblings, and parents, using a structured interview. A blood sample (40mls) will be obtained from all participants. Photos will be collected from twins in order to accurately measure advancement of individual hair loss.

Common baldness (androgenetic alopecia, AGA) is the most common form of hair loss in humans. In caucasians, normal male hair loss, commonly known as "male pattern baldness" (MPB), is noticeable in about 20% of men aged 20, and continues to steadily increase with age, so that a male in his 90's has a 90% chance of having some degree of MPB. The negative psychosocial effects associated with male hair loss include decreased self-esteem, dissatisfaction with body image or appearance, self-consciousness, perception of aging and often emotional stress. Furthermore, these effects tend to be more pronounced in younger men.