Rationale and Scientific Aims of the Project
Twin studies comparing identical and non identical twins are useful in determining the relative genetic and environmental contributions to disease. Recent work has shown glaucoma genes contribute to the development of glaucoma. The extent of this contribution and the interaction with environmental factors is not clear.
We wish to examine around 100 sets of identical twins, 100 sets of non identical twins who are not known to be affected by glaucoma and approximately 50 sets of twins (both identical and non identical) who stated that they were affected by glaucoma and their siblings.
The examination will be a routine glaucoma screen of visual field testing, intraocular pressure measurement and optic disc photography.
This work builds on The
Glaucoma Inheritance Study (GIST) being conducted at the Glaucoma Unit, Royal
Victorian Eye and