Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
986976
TITLE
Genetic models for the analysis of data from the families of identical twins.
ABSTRACT
Genetic models are described which exploit the unique relationships that exist within the families of identical twins to obtain weighted least squares estimates of additive, dominance and epistatic components of genetic variance as well as estimates of the contributions of X-linked genes, maternal effects and three sources of environmental variation. Since all of the relationships required to achieve a resolution of these variance components are contained within each family unit, the model would appear to be superior to previous approaches to the analysis of quantitative traits in man.
DATE PUBLISHED
1976 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1976/08/01
medline 1976/08/01 00:01
entrez 1976/08/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Nance WE Nance W E WE
Corey LA Corey L A LA
INVESTIGATORS
JOURNAL
VOLUME: 83
ISSUE: 4
TITLE: Genetics
ISOABBREVIATION: Genetics
YEAR: 1976
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0016-6731
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genetics
COUNTRY: United States
ISSNLINKING: 0016-6731
NLMUNIQUEID: 0374636
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Biometry
Environment
Female
Genes, Dominant
Genetic Linkage
Genetic Variation
Humans
Models, Biological
Pregnancy
Sex Chromosomes
Twins
Twins, Monozygotic
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's