Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
9836715
TITLE
Smoking, obesity, and hypertension alter the dose-response curve and test sensitivity of carbohydrate-deficient transferrin as a marker of alcohol intake.
ABSTRACT
Serum carbohydrate-deficient transferrin (CDT) is a specific and comparatively sensitive marker of excessive alcohol use; however, reports of its sensitivity vary according to the population or patient groups studied and their average alcohol intake. We have characterized the dose-response curve between alcohol intake and CDT concentrations in a study of 1400 men and women from a community-based twin registry. Our results show that mean CDT increases with increasing reported alcohol consumption even within the range of alcohol use considered to be nonhazardous. We found significant effects of sex, age, smoking, previous alcohol dependence, body mass index, and diastolic hypertension on the alcohol-CDT dose-response curve. These variables either affect test sensitivity or require adjustment of reference intervals. The results also provide insight into the physiological and biochemical factors that affect CDT concentration.
DATE PUBLISHED
1998 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1998/12/04
medline 1998/12/04 00:01
entrez 1998/12/04 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whitfield JB Whitfield J B JB 1 Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia. johnwhit@bioc.rpa.cs.nsw.gov.au
Fletcher LM Fletcher L M LM
Murphy TL Murphy T L TL
Powell LW Powell L W LW
Halliday J Halliday J J
Heath AC Heath A C AC
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 44
ISSUE: 12
TITLE: Clinical chemistry
ISOABBREVIATION: Clin. Chem.
YEAR: 1998
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0009-9147
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Clin Chem
COUNTRY: United States
ISSNLINKING: 0009-9147
NLMUNIQUEID: 9421549
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age Factors
Aged
Aged, 80 and over
Alcohol Drinking physiopathology
Alcoholism blood
Australia blood
Biological Markers blood
Blood Pressure blood
Dose-Response Relationship, Drug blood
Female blood
Humans blood
Hypertension physiopathology
Male physiopathology
Middle Aged physiopathology
Obesity blood
Reference Values blood
Sensitivity and Specificity blood
Sex Factors blood
Smoking blood
Transferrin analysis
Twins analysis
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Biological Markers
0 Transferrin
0 carbohydrate-deficient transferrin
OTHER ID's