Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
9806475
TITLE
Molecular biology of alcohol dependence, a complex polygenic disorder.
ABSTRACT
Alcohol dependence, and the medical conditions which arise from prolonged excessive alcohol use, have no single cause. Like other complex diseases, they result from a combination of social, personal and genetic contributions; but within any society genetic variation has a substantial influence on individual risk. The genes presently known to affect alcohol dependence produce variation in alcohol metabolism; other genes which affect personality or susceptibility to intoxication are likely to be significant but so far reproducible evidence is scanty. Designs which include related subjects have advantages for the study of complex diseases, because any association effects can be placed in the context of overall heritability and because linkage analysis can also be included. Examples of our studies of alcohol metabolism, consumption and dependence are presented.
DATE PUBLISHED
1998 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1998/11/07
medline 1998/11/07 00:01
entrez 1998/11/07 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whitfield JB Whitfield J B JB Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia. johnwhit@bioc.rpa.cs.nsw.gov.au
Nightingale BN Nightingale B N BN
O'Brien ME O'Brien M E ME
Heath AC Heath A C AC
Birley AJ Birley A J AJ
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 36
ISSUE: 8
TITLE: Clinical chemistry and laboratory medicine : CCLM / FESCC
ISOABBREVIATION: Clin. Chem. Lab. Med.
YEAR: 1998
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1434-6621
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Clin Chem Lab Med
COUNTRY: Germany
ISSNLINKING: 1434-6621
NLMUNIQUEID: 9806306
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Alcohol Dehydrogenase genetics
Alcoholism genetics
Female genetics
Genetic Predisposition to Disease genetics
Humans genetics
Male genetics
Risk Factors genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
EC 1.1.1.1 Alcohol Dehydrogenase
OTHER ID's