Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
9517600
TITLE
Genetic and environmental risk factors for asthma: a cotwin-control study.
ABSTRACT
In complex diseases of genetic etiology such as asthma and atopy, it is difficult to differentiate causes of disease from consequences, and quantitate the importance of such causative factors. We examined possible risk factors for the development of wheezing and bronchial hyperresponsiveness in a cotwin-control study nested within a larger community-based twin-family study. In 62 monozygotic (MZ) twin pairs discordant for a history of wheezing, skin prick test to house dust extract was the most important discriminator, followed by sensitization to cat and cockroach allergens. In contrast, 62 dizygotic (DZ) discordant twin pairs differed additionally in sensitization to grass pollens and fungi. Markers such as serum haptoglobin, serum magnesium, and alpha-1-antitrypsin levels did not differ significantly between discordant twins. This MZ/DZ difference suggests that pollen allergy in asthmatics is more an epiphenomenon due to a genetic correlation between asthma and the allergic diathesis, whereas indoor allergens are likely to be direct environmental causes of asthma.
DATE PUBLISHED
1998 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1998/03/28
medline 1998/03/28 00:01
entrez 1998/03/28 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Duffy DL Duffy D L DL Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia.
Mitchell CA Mitchell C A CA
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 157
ISSUE: 3 Pt 1
TITLE: American journal of respiratory and critical care medicine
ISOABBREVIATION: Am. J. Respir. Crit. Care Med.
YEAR: 1998
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1073-449X
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Respir Crit Care Med
COUNTRY: UNITED STATES
ISSNLINKING: 1073-449X
NLMUNIQUEID: 9421642
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Air Pollution, Indoor adverse effects
Allergens adverse effects
Animals adverse effects
Asthma genetics
Biological Markers blood
Bronchial Hyperreactivity physiopathology
Case-Control Studies physiopathology
Cats physiopathology
Causality physiopathology
Cockroaches immunology
Diseases in Twins immunology
Dust adverse effects
Environment adverse effects
Female adverse effects
Fungi immunology
Hair immunology
Haptoglobins genetics
Humans genetics
Hypersensitivity genetics
Magnesium blood
Male blood
Middle Aged blood
Poaceae immunology
Pollen adverse effects
Respiratory Sounds genetics
Risk Factors genetics
Skin Tests genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
alpha 1-Antitrypsin genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Allergens
0 Biological Markers
0 Dust
0 Haptoglobins
0 alpha 1-Antitrypsin
I38ZP9992A Magnesium
OTHER ID's