Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
9403910
TITLE
Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Genetic influences on alcoholism risk are well-documented in men, but uncertain in women. We tested for gender differences in genetic influences on, and risk-factors for, DSM-III-R alcohol dependence (AD).
METHOD NlmCategory: METHODS
Diagnostic follow-up interviews were conducted in 1992-3 by telephone with twins from an Australian twin panel first surveyed in 1980-82 (N = 5889 respondents). Data were analysed using logistic regression models.
RESULTS NlmCategory: RESULTS
Significantly higher twin pair concordances were observed in MZ compared to DZ same-sex twin pairs in women and men, even when data were weighted to adjust for over-representation of well-educated respondents, and for selective attrition. AD risk was increased in younger birth cohorts, in Catholic males or women reporting no religious affiliation, in those reporting a history of conduct disorder or major depression and in those with high Neuroticism, Social Non-conformity, Toughmindedness, Novelty-Seeking or (in women only) Extraversion scores; and decreased in 'Other Protestants', weekly church attenders, and university-educated males. Controlling for these variables, however, did not remove the significant association with having an alcoholic MZ co-twin, implying that much of the genetic influence on AD risk remained unexplained. No significant gender difference in the genetic variance in AD was found (64% heritability, 95% confidence interval 32-73%).
CONCLUSIONS NlmCategory: CONCLUSIONS
Genetic risk-factors play as important a role in determining AD risk in women as in men. With the exception of certain sociocultural variables such as religious affiliation, the same personality, sociodemographic and axis I correlates of alcoholism risk are observed in women and men.
DATE PUBLISHED
1997 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1997/12/24
medline 1997/12/24 00:01
entrez 1997/12/24 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Heath AC Heath A C AC Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA.
Bucholz KK Bucholz K K KK
Madden PA Madden P A PA
Dinwiddie SH Dinwiddie S H SH
Slutske WS Slutske W S WS
Bierut LJ Bierut L J LJ
Statham DJ Statham D J DJ
Dunne MP Dunne M P MP
Whitfield JB Whitfield J B JB
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 27
ISSUE: 6
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 1997
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0033-2917
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Alcoholism genetics
Australia epidemiology
Catholicism epidemiology
Diseases in Twins genetics
Female genetics
Humans genetics
Logistic Models genetics
Male genetics
Middle Aged genetics
Models, Genetic genetics
Odds Ratio genetics
Personality classification
Prevalence classification
Registries classification
Risk Factors classification
Severity of Illness Index classification
Sex Factors classification
Twins, Dizygotic classification
Twins, Monozygotic classification
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's