Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
9398838
TITLE
A twin-pronged attack on complex traits.
ABSTRACT
Before one starts the hunt for quantitative trait loci (QTLs) for a complex trait, it is necessary to show that the trait is genetically influenced. This evidence is most likely to come from the classical twin study--the demonstration that monozygotic twins are more similar for the trait than dizygotic twins. The strengths and weaknesses of twin studies are discussed, and it is suggested that, far from becoming irrelevant with advances in molecular biology, they can improve the efficiency of QTL detection and play an important role in unravelling developmental genetic mechanisms.
DATE PUBLISHED
1997 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1997/12/17
medline 1997/12/17 00:01
entrez 1997/12/17 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Martin N Martin N N Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia. nickM@qimr.edu.au
Boomsma D Boomsma D D
Machin G Machin G G
INVESTIGATORS
JOURNAL
VOLUME: 17
ISSUE: 4
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 1997
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1061-4036
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Review
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Diseases in Twins genetics
Genetic Linkage genetics
Genetic Markers genetics
Humans genetics
Models, Genetic genetics
Multivariate Analysis genetics
Quantitative Trait, Heritable genetics
Social Environment genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Genetic Markers
OTHER ID's