Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
8349859
TITLE
Psoriasis in Australian twins.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Occurrence of psoriasis has been found to be strongly genetically controlled in Northern European and U.S. twin and family studies.
OBJECTIVE NlmCategory: OBJECTIVE
Our purpose was to assess cumulative incidence and heritability of psoriasis in the Australian population.
METHODS NlmCategory: METHODS
Australian twins reporting psoriasis on a screening questionnaire received from 3808 pairs were mailed a detailed instrument designed to validate the diagnosis, supplemented by telephone interview and examination of medical records.
RESULTS NlmCategory: RESULTS
Only 94 of 160 subjects who screened positive were confirmed to have psoriasis. The cumulative incidence of confirmed psoriasis was 2% in 30- to 60-year-old subjects. The monozygotic twin casewise concordance for confirmed psoriasis was 35% (12 of 34 pairs), and the dizygotic twin concordance 12% (5 of 43 pairs), giving an estimated heritability of 80%, was similar to that found in a genetic reanalysis of three previous twin studies. A case-control analysis of psoriasis-discordant twin pairs found no evidence for influences of alcohol or coffee intake, overweight, birth weight, or personality in the origin of psoriasis.
CONCLUSION NlmCategory: CONCLUSIONS
Occurrence of psoriasis in the Australian population is highly heritable, but identical twins are often discordant; the factor responsible for the onset of disease in one twin and not the other is unclear.
DATE PUBLISHED
1993 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1993/09/01
medline 1993/09/01 00:01
entrez 1993/09/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Duffy DL Duffy D L DL Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Spelman LS Spelman L S LS
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 29
ISSUE: 3
TITLE: Journal of the American Academy of Dermatology
ISOABBREVIATION: J. Am. Acad. Dermatol.
YEAR: 1993
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0190-9622
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: J Am Acad Dermatol
COUNTRY: UNITED STATES
ISSNLINKING: 0190-9622
NLMUNIQUEID: 7907132
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia epidemiology
Case-Control Studies epidemiology
Diseases in Twins epidemiology
Female epidemiology
Follow-Up Studies epidemiology
Humans epidemiology
Male epidemiology
Middle Aged epidemiology
Observer Variation epidemiology
Psoriasis epidemiology
Questionnaires epidemiology
Twins, Dizygotic epidemiology
Twins, Monozygotic epidemiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's