Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
8332656
TITLE
Panic disorder in women: a population-based twin study.
ABSTRACT
Previous studies based on probands from clinical samples suggest that panic disorder aggregates strongly in families and may be due to a highly penetrant single major locus. In this study we examine panic disorder as assessed at blind, structured psychiatric interview in 2163 women from a population-based twin registry. DSM-III-R diagnoses were assigned at a narrow and at a broad level both by clinician review and by computer algorithm. The familial aggregation of panic disorder in this sample was only modest. The relatively small number of affected individuals prevented a definitive resolution of competing genetic and non-genetic models of familial transmission. Although there was some inconsistency across diagnostic approaches, most results suggested that the familial aggregation of panic disorder was due largely to genetic factors. Using a multifactorial-threshold model, the best estimates of the heritability of liability ranged from 30 to 40%. From a familial perspective, panic disorder with phobic avoidance appears to represent a more severe form of the syndrome than panic disorder without avoidance. Our results, which suggest that in the general population panic disorder is only a moderately heritable condition, are at variance with results from several previous investigations based on clinically ascertained samples.
DATE PUBLISHED
1993 May
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1993/05/01
medline 1993/05/01 00:01
entrez 1993/05/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kendler KS Kendler K S KS Department of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298-0710.
Neale MC Neale M C MC
Kessler RC Kessler R C RC
Heath AC Heath A C AC
Eaves LJ Eaves L J LJ
INVESTIGATORS
JOURNAL
VOLUME: 23
ISSUE: 2
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 1993
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0033-2917
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
CommentIn Psychol Med. 1994 Feb;24(1):259-60 8208890
GRANTS
GRANTID AGENCY COUNTRY
HD-26746 NICHD NIH HHS United States
MH-40828 NIMH NIH HHS United States
NS-25630 NINDS NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Diseases in Twins psychology
Female psychology
Humans psychology
Models, Genetic psychology
Panic Disorder psychology
Psychiatric Status Rating Scales psychology
Risk Factors psychology
Social Environment psychology
Twins, Dizygotic psychology
Twins, Monozygotic psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's