Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
8314060
TITLE
Risk factors for atherosclerosis in twins.
ABSTRACT
We performed multivariate genetic analyses of cardiovascular risk factors from two sets of data on US and Australian female twins. Similar models for body mass index (BMI), serum low density (LDL) and high density (HDL) lipoproteins, including age as a covariate, were fitted successfully to both groups. These suggested that BMI, or genes responsible for a significant proportion of the variance of BMI, explained correlations between lipid subfractions, as well as those between blood pressure and lipid subfractions, especially HDL.
DATE PUBLISHED
1993
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1993/01/01
medline 1993/01/01 00:01
entrez 1993/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Duffy DL Duffy D L DL Queensland Institute of Medical Research, Brisbane, Australia.
O'Connell DL O'Connell D L DL
Heller RF Heller R F RF
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 10
ISSUE: 6
TITLE: Genetic epidemiology
ISOABBREVIATION: Genet. Epidemiol.
YEAR: 1993
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0741-0395
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genet Epidemiol
COUNTRY: United States
ISSNLINKING: 0741-0395
NLMUNIQUEID: 8411723
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Arteriosclerosis genetics
Australia epidemiology
Blood Pressure epidemiology
Body Mass Index epidemiology
Diseases in Twins genetics
Female genetics
Humans genetics
Lipoproteins, HDL genetics
Lipoproteins, LDL genetics
Middle Aged genetics
Multivariate Analysis genetics
Risk Factors genetics
Twins, Dizygotic statistics & numerical data
Twins, Monozygotic statistics & numerical data
United States epidemiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Lipoproteins, HDL
0 Lipoproteins, LDL
OTHER ID's