Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
8086594
TITLE
Probability of gene identity by descent: computation and applications.
ABSTRACT
Two genes at a given locus are identical by descent (IBD) if both have been inherited from a common ancestor. We present an algorithm for computing the probabilities of all IBD relationships among the genes of pedigree members. We show how to use these probabilities to calculate the probability of any combination of genotypes or phenotypes for the pedigree members. Applications to linkage analysis and genetic counseling are illustrated with examples. The algorithm also can be used to calculate the generalized kinship coefficients proposed by others.
DATE PUBLISHED
1994 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1994/03/01
medline 1994/03/01 00:01
entrez 1994/03/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whittemore AS Whittemore A S AS Department of Health Research and Policy, Stanford University School of Medicine, California 94305.
Halpern J Halpern J J
INVESTIGATORS
JOURNAL
VOLUME: 50
ISSUE: 1
TITLE: Biometrics
ISOABBREVIATION: Biometrics
YEAR: 1994
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0006-341X
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Biometrics
COUNTRY: United States
ISSNLINKING: 0006-341X
NLMUNIQUEID: 0370625
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
CA 47448 NCI NIH HHS United States
GM 21215 NIGMS NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Algorithms
Biometry methods
Female methods
Genetic Counseling methods
Genetic Linkage methods
Genotype methods
Humans methods
Male methods
Models, Genetic methods
Pedigree methods
Phenotype methods
Probability methods
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's