Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
7939663
TITLE
Quantitative trait locus for reading disability on chromosome 6.
ABSTRACT
Interval mapping of data from two independent samples of sib pairs, at least one member of whom was reading disabled, revealed evidence for a quantitative trait locus (QTL) on chromosome 6. Results obtained from analyses of reading performance from 114 sib pairs genotyped for DNA markers localized the QTL to 6p21.3. Analyses of corresponding data from an independent sample of 50 dizygotic twin pairs provided evidence for linkage to the same region. In combination, the replicate samples yielded a chi 2 value of 16.73 (P = 0.0002). Examination of twin and kindred siblings with more extreme deficits in reading performance yielded even stronger evidence for a QTL (chi 2 = 27.35, P < 0.00001). The position of the QTL was narrowly defined with a 100:1 confidence interval to a 2-centimorgan region within the human leukocyte antigen complex.
DATE PUBLISHED
1994 Oct 14
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1994/10/14
medline 1994/10/14 00:01
entrez 1994/10/14 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Cardon LR Cardon L R LR Health Sciences Program, SRI International, Menlo Park, CA 94025.
Smith SD Smith S D SD
Fulker DW Fulker D W DW
Kimberling WJ Kimberling W J WJ
Pennington BF Pennington B F BF
DeFries JC DeFries J C JC
INVESTIGATORS
JOURNAL
VOLUME: 266
ISSUE: 5183
TITLE: Science (New York, N.Y.)
ISOABBREVIATION: Science
YEAR: 1994
MONTH: Oct
DAY: 14
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0036-8075
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Science
COUNTRY: United States
ISSNLINKING: 0036-8075
NLMUNIQUEID: 0404511
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
CommentIn Science. 1995 May 12;268(5212):786-8 7605493
ErratumIn Science. 1995 Jun 16;268(5217):1553 7777847
GRANTS
GRANTID AGENCY COUNTRY
HD-11681 NICHD NIH HHS United States
HD-27802 NICHD NIH HHS United States
HG-00085 NHGRI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Alleles
Child
Chromosome Mapping
Chromosomes, Human, Pair 6
Diseases in Twins genetics
Dyslexia genetics
Female genetics
Genetic Linkage genetics
Genetic Markers genetics
HLA Antigens genetics
Humans genetics
Major Histocompatibility Complex genetics
Male genetics
Nuclear Family genetics
Regression Analysis genetics
Twins, Dizygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Genetic Markers
0 HLA Antigens
OTHER ID's