Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
7779124
TITLE
Osteoporosis in rheumatoid arthritis. A monozygotic co-twin control study.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
To quantify the magnitude and distribution of osteoporosis in rheumatoid arthritis (RA).
METHODS NlmCategory: METHODS
Bone mineral density (BMD) was measured by dual x-ray absorptiometry, in a monozygotic co-twin control study.
RESULTS NlmCategory: RESULTS
BMD was reduced at most skeletal sites in the twin with RA compared with the co-twin (lumbar spine 4.6%, femoral neck 9.7%, total body 5.7%). Differences in lean soft tissue (5.6% for total body) correlated with differences in BMD between twins at multiple sites.
CONCLUSION NlmCategory: CONCLUSIONS
Osteoporosis in RA is generalized and may be related to loss of mobility or muscle mass associated with the disease.
DATE PUBLISHED
1995 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1995/06/01
medline 1995/06/01 00:01
entrez 1995/06/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Sambrook PN Sambrook P N PN Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, Australia.
Spector TD Spector T D TD
Seeman E Seeman E E
Bellamy N Bellamy N N
Buchanan RR Buchanan R R RR
Duffy DL Duffy D L DL
Martin NG Martin N G NG
Prince R Prince R R
Owen E Owen E E
Silman AJ Silman A J AJ
INVESTIGATORS
JOURNAL
VOLUME: 38
ISSUE: 6
TITLE: Arthritis and rheumatism
ISOABBREVIATION: Arthritis Rheum.
YEAR: 1995
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0004-3591
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Arthritis Rheum
COUNTRY: UNITED STATES
ISSNLINKING: 0004-3591
NLMUNIQUEID: 0370605
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Arthritis, Rheumatoid genetics
Bone Density physiology
Diseases in Twins genetics
Female genetics
Femur Neck physiopathology
Great Britain epidemiology
Humans epidemiology
Lumbar Vertebrae physiopathology
Male physiopathology
Osteoporosis genetics
Questionnaires genetics
Registries genetics
Regression Analysis genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's