Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
7581446
TITLE
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.
ABSTRACT
Genetic studies are under way for many complex traits, spurred by the recent feasibility of whole genome scans. Clear guidelines for the interpretation of linkage results are needed to avoid a flood of false positive claims. At the same time, an overly cautious approach runs the risk of causing true hints of linkage to be missed. We address this problem by proposing specific standards designed to maintain rigor while also promoting communication.
DATE PUBLISHED
1995 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1995/11/01
medline 1995/11/01 00:01
entrez 1995/11/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Lander E Lander E E Whitehead Institute for Biomedical Research, Cambridge Massachusetts 02142, USA.
Kruglyak L Kruglyak L L
INVESTIGATORS
JOURNAL
VOLUME: 11
ISSUE: 3
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 1995
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1061-4036
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
CommentIn Nat Genet. 1995 Nov;11(3):223-4 7581436
CommentIn Nat Genet. 1996 Oct;14(2):132-3 8841180
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Genetic Linkage
Genetics standards
Genome standards
Lod Score standards
Models, Genetic standards
Research Design standards
Statistics as Topic standards
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's