Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
7573778
TITLE
Is alcohol-related flushing a protective factor for alcoholism in Caucasians?
ABSTRACT
Although alcohol-related flushing seems to be a genetically influenced protective factor for alcoholism in some Asian groups, little is known about whether this is true for Caucasians. The evidence for alcohol-related flushing as a protective factor for the development of alcoholism was examined in a sample of 5831 Australian twins (2041 men, 3790 women) who were administered a structured psychiatric interview. Twin correlations for self-reported adverse alcohol reactions (e.g., "flushing or blushing" and "feeling very sleepy" after drinking 1 or 2 drinks) were modest, suggesting minimal contribution of genetic factors, but when corrected for reliability of measurement, were consistent with moderate heritabilities. In accord with studies examining Asian samples, we found that individuals who experienced adverse reactions after drinking small amounts of alcohol drank less often and slightly less per drinking occasion than those who did not experience adverse reactions. However, those who experienced adverse reactions were more likely to have symptoms of alcoholism and to report a parental history of alcohol problems. We conclude that self-reported alcohol-related flushing is not a protective factor for alcoholism in Caucasians and may be a risk factor.
DATE PUBLISHED
1995 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1995/06/01
medline 1995/06/01 00:01
entrez 1995/06/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Slutske WS Slutske W S WS Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Heath AC Heath A C AC
Madden PA Madden P A PA
Bucholz KK Bucholz K K KK
Dinwiddie SH Dinwiddie S H SH
Dunne MP Dunne M P MP
Statham DS Statham D S DS
Whitfield JB Whitfield J B JB
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 19
ISSUE: 3
TITLE: Alcoholism, clinical and experimental research
ISOABBREVIATION: Alcohol. Clin. Exp. Res.
YEAR: 1995
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0145-6008
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Alcohol Clin Exp Res
COUNTRY: England
ISSNLINKING: 0145-6008
NLMUNIQUEID: 7707242
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
MH17104 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Alcohol Drinking psychology
Alcoholism psychology
Australia psychology
Child of Impaired Parents psychology
Diseases in Twins psychology
European Continental Ancestry Group genetics
Female genetics
Flushing psychology
Humans psychology
Male psychology
Middle Aged psychology
Risk Factors psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's