Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
6685961
TITLE
Inheritance and alcohol as factors influencing plasma uric acid levels.
ABSTRACT
Variation in plasma uric acid levels in 206 pairs of male and female twins, aged from 18 to 34 years, was consistent with a simple model including only individual environmental and additive genetic effects and a heritability of h2 = 0.73. Individual environmental variation was estimated to be approximately the same as variation of individuals measured on two occasions. Correlations of DZ pairs were also consistent with sex-linked genetic effects. In men there was a significant genetic correlation with weekly alcohol consumption and as much as 18% of the variation in uric acid levels could be accounted for by genetic variation in alcohol consumption.
DATE PUBLISHED
1983
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1983/01/01
medline 1983/01/01 00:01
entrez 1983/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whitfield JB Whitfield J B JB
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 32
ISSUE: 2
TITLE: Acta geneticae medicae et gemellologiae
ISOABBREVIATION: Acta Genet Med Gemellol (Roma)
YEAR: 1983
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0001-5660
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Acta Genet Med Gemellol (Roma)
COUNTRY: ITALY
ISSNLINKING: 0001-5660
NLMUNIQUEID: 0370314
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Alcohol Drinking
Environment
Female
Genetic Linkage
Genetic Variation
Humans
Male
Models, Genetic
Pregnancy
Twins, Dizygotic
Twins, Monozygotic
Uric Acid blood
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
268B43MJ25 Uric Acid
OTHER ID's