Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
6684513
TITLE
Do the MN and Jk systems influence environmental variability in serum lipid levels?
ABSTRACT
Significant heterogeneity in the distribution of within pair variances of serum total cholesterol, HDL cholesterol, non HDL cholesterol and triglyceride levels has been found in one or both of two samples of MZ twins. We have found some support for the observation of Magnus et al. (1981) that M- pairs have greater environmental variability in cholesterol levels than M+ pairs and weaker evidence that Jka+ pairs are more variable than Jka- pairs. However, these effects appear to be more striking on triglyceride levels. The low power of the variance ratio test is advanced as a possible reason for the inconsistencies in these findings.
DATE PUBLISHED
1983 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1983/07/01
medline 1983/07/01 00:01
entrez 1983/07/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Martin NG Martin N G NG
Rowell DM Rowell D M DM
Whitfield JB Whitfield J B JB
INVESTIGATORS
JOURNAL
VOLUME: 24
ISSUE: 1
TITLE: Clinical genetics
ISOABBREVIATION: Clin. Genet.
YEAR: 1983
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0009-9163
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Clin Genet
COUNTRY: DENMARK
ISSNLINKING: 0009-9163
NLMUNIQUEID: 0253664
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Analysis of Variance
Ascorbic Acid pharmacology
Blood Group Antigens genetics
Cholesterol blood
Cholesterol, HDL blood
Environment blood
Female blood
Genotype blood
Humans blood
Kidd Blood-Group System genetics
Lipids genetics
Lipoproteins, HDL blood
MNSs Blood-Group System genetics
Male genetics
Middle Aged genetics
Pregnancy genetics
Triglycerides blood
Twins blood
Twins, Monozygotic blood
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Blood Group Antigens
0 Cholesterol, HDL
0 Kidd Blood-Group System
0 Lipids
0 Lipoproteins, HDL
0 MNSs Blood-Group System
0 Triglycerides
97C5T2UQ7J Cholesterol
PQ6CK8PD0R Ascorbic Acid
OTHER ID's