Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
6684395
TITLE
Determinants of variation in plasma alkaline phosphatase activity: a twin study.
ABSTRACT
Plasma alkaline phosphatase activity has been measured in 204 pairs of twins aged 18-34. Estimated genetic variance was the same in men and women, after exclusion of the youngest men, but environmental variance was greater in men so that the heritability was .90 +/- .02 in the women and .71 +/- .05 in the 19-34-year-old men. About 15% of the genetic variance was associated with the ABO blood group polymorphism, which is known to affect intestinal alkaline phosphatase. Differences in plasma alkaline phosphatase activity between normal people may be mainly due to genetically determined proportions of isoenzymes of differing stability.
DATE PUBLISHED
1983 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1983/09/01
medline 1983/09/01 00:01
entrez 1983/09/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whitfield JB Whitfield J B JB
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 35
ISSUE: 5
TITLE: American journal of human genetics
ISOABBREVIATION: Am. J. Hum. Genet.
YEAR: 1983
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0002-9297
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Hum Genet
COUNTRY: United States
ISSNLINKING: 0002-9297
NLMUNIQUEID: 0370475
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
ABO Blood-Group System genetics
Adolescent genetics
Adult genetics
Alkaline Phosphatase genetics
Environment genetics
Female genetics
Genetic Variation genetics
Humans genetics
Male genetics
Models, Genetic genetics
Polymorphism, Genetic genetics
Pregnancy genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 ABO Blood-Group System
EC 3.1.3.1 Alkaline Phosphatase
OTHER ID's
OTHERID SOURCE
PMC1685834 NLM