Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
6544238
TITLE
The resolution of genotype x environment interaction in segregation analysis of nuclear families.
ABSTRACT
A model is presented for the effects of one or two loci, a measured index of the environment and genotype x environment (G x E) interaction of risk for a discontinuous trait. Initial properties of the model are explored for the single locus case, with and without the effects of environment and G x E interaction. Seven data sets were simulated, each comprising 500 nuclear families on whom an environmental index has been measured. Maximum-likelihood estimation procedures were used to obtain parameter estimates under seven models for each data set. Likelihood ratio tests were constructed, and in all cases it was possible to identify the "correct" model for the simulated data. The matrices of information realized showed that the parameters could be estimated with acceptable precision and that the effects of genes, environment, and G x E interaction could be resolved in the simulated populations. The effects on conventional segregation analysis of ignoring the environment and G x E are considered.
DATE PUBLISHED
1984
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1984/01/01
medline 1984/01/01 00:01
entrez 1984/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Eaves LJ Eaves L J LJ
INVESTIGATORS
JOURNAL
VOLUME: 1
ISSUE: 3
TITLE: Genetic epidemiology
ISOABBREVIATION: Genet. Epidemiol.
YEAR: 1984
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0741-0395
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genet Epidemiol
COUNTRY: United States
ISSNLINKING: 0741-0395
NLMUNIQUEID: 8411723
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
GM80520-01 NIGMS NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Biometry
Environment
Female
Genotype
Heterozygote
Homozygote
Humans
Male
Models, Genetic
Nuclear Family
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's