Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
6430084
TITLE
A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes.
ABSTRACT
Two widely used affected-sib-pair scoring procedures (the Green and Woodrow [1977] procedure, and the method of forming all possible affected-sib-pairs) are compared with a new method for their relative efficiency in detecting the presence of an HLA-linked disease susceptibility gene. Their relative performance is investigated by extensive computer simulations over a large number of disease transmission models. On the average, the new procedure appears to outperform the Green and Woodrow method and the "all-possible-pairs" method.
DATE PUBLISHED
1984 May
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1984/05/01
medline 1984/05/01 00:01
entrez 1984/05/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Suarez BK Suarez B K BK
Van Eerdewegh P Van Eerdewegh P P
INVESTIGATORS
JOURNAL
VOLUME: 18
ISSUE: 1
TITLE: American journal of medical genetics
ISOABBREVIATION: Am. J. Med. Genet.
YEAR: 1984
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0148-7299
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet
COUNTRY: United States
ISSNLINKING: 0148-7299
NLMUNIQUEID: 7708900
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
GM 28719 NIGMS NIH HHS United States
MH 14677 NIMH NIH HHS United States
MH 31302 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Computers
Disease Susceptibility
Genes, MHC Class II
Genetic Linkage
HLA-DQ Antigens
Histocompatibility Antigens Class II genetics
Humans genetics
Models, Genetic genetics
Pedigree genetics
Phenotype genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 HLA-DQ Antigens
0 Histocompatibility Antigens Class II
OTHER ID's