Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
4054596
TITLE
Genetic and environmental influences on the size and number of cells in the blood.
ABSTRACT
The heritabilities of human blood cell characteristics were estimated in a study of 206 pairs of young adult twins, male and female. White cell numbers, indices related to circulating red cell mass (haemoglobin, red cell count, and haematocrit), and platelet numbers and size all appeared to be accounted for by genetic and nonshared environmental influences only. Mean cell volume (of the erythrocytes) appeared to be influenced by environmental factors shared by siblings as well as the other two sources of variation. Correlation between red cell count and haemoglobin is modulated by both genetic and environmental factors, but the negative correlation between red cell numbers and size is due mainly to genetic factors independent of those influencing haemoglobin. A significant negative correlation also exists between platelet numbers and size. In males, alcohol consumption increased mean cell volume, and genetic factors influencing alcohol consumption are partly responsible for the correlation between them.
DATE PUBLISHED
1985
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1985/01/01
medline 1985/01/01 00:01
entrez 1985/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whitfield JB Whitfield J B JB
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 2
ISSUE: 2
TITLE: Genetic epidemiology
ISOABBREVIATION: Genet. Epidemiol.
YEAR: 1985
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0741-0395
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genet Epidemiol
COUNTRY: United States
ISSNLINKING: 0741-0395
NLMUNIQUEID: 8411723
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Alcohol Drinking
Blood Cell Count
Blood Cells cytology
Environment cytology
Erythrocyte Count cytology
Female cytology
Genetics, Medical cytology
Hematocrit cytology
Hemoglobins analysis
Humans analysis
Male analysis
Twins analysis
Twins, Dizygotic analysis
Twins, Monozygotic analysis
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Hemoglobins
OTHER ID's