Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
4054590
TITLE
Genetic and environmental causes of variation in renal tubular handling of sodium and potassium: a twin study.
ABSTRACT
We have conducted a study of renal sodium and potassium reabsorption in 205 pairs of twins on freely chosen diets; 89 of the subjects were studied on more than one occasion. Renal tubular sodium and potassium handling, as measured by the fractional excretions FENa and FEK, show repeatable differences between individuals. Siblings (in this case monozygotic and dizygotic pairs of twins) are more alike in this respect than unrelated individuals. Comparison of monozygotic and dizygotic twin pairs indicates that genetic, rather than shared environmental, factors are probably responsible for this similarity, with heritability estimates of 0.5 for sodium and 0.6 for potassium. There are indications of sex differences in the sizes of the genetic and environmental effects for both variables and indications that the genetic effects may be qualitatively different for FEK. Such findings need further investigation.
DATE PUBLISHED
1985
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1985/01/01
medline 1985/01/01 00:01
entrez 1985/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whitfield JB Whitfield J B JB
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 2
ISSUE: 1
TITLE: Genetic epidemiology
ISOABBREVIATION: Genet. Epidemiol.
YEAR: 1985
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0741-0395
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genet Epidemiol
COUNTRY: United States
ISSNLINKING: 0741-0395
NLMUNIQUEID: 8411723
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Female
Genetic Variation
Genotype
Humans
Kidney Tubules metabolism
Male metabolism
Models, Genetic metabolism
Potassium metabolism
Sex Factors metabolism
Sodium metabolism
Twins metabolism
Twins, Dizygotic metabolism
Twins, Monozygotic metabolism
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
9NEZ333N27 Sodium
RWP5GA015D Potassium
OTHER ID's