Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
3953861
TITLE
Models for the joint effect of genotype and environment on liability to psychiatric illness.
ABSTRACT
The authors present three major models for the joint effect of genes and environment on liability to psychiatric illness: additive effects of genotype and environment, genetic control of sensitivity to the environment, and genetic control of exposure to the environment. Each model is illustrated by several examples, including a quantitative one. The authors attempt to demonstrate that genes and the environment can interact in several interesting and potentially subtle ways, that these interactions can be expressed in simple models from which clear empirical predictions can be generated, and that elucidation of the etiology of psychiatric disorders will require the consideration of both genetic and environmental risk factors.
DATE PUBLISHED
1986 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1986/03/01
medline 1986/03/01 00:01
entrez 1986/03/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kendler KS Kendler K S KS
Eaves LJ Eaves L J LJ
INVESTIGATORS
JOURNAL
VOLUME: 143
ISSUE: 3
TITLE: The American journal of psychiatry
ISOABBREVIATION: Am J Psychiatry
YEAR: 1986
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0002-953X
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Psychiatry
COUNTRY: United States
ISSNLINKING: 0002-953X
NLMUNIQUEID: 0370512
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
GM-30520 NIGMS NIH HHS United States
GM-32732 NIGMS NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Depressive Disorder genetics
Diseases in Twins genetics
Genes genetics
Genotype genetics
Humans genetics
Mental Disorders genetics
Models, Genetic genetics
Models, Theoretical genetics
Research Design genetics
Risk genetics
Schizophrenia genetics
Smoking genetics
Social Environment genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's