Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
3751470
TITLE
Genetic variation and plasma creatine kinase activity.
ABSTRACT
The distribution of plasma creatine kinase (CK; E.C.2.7.3.2) is known to be skewed, and this has made it difficult to analyse the sources of variation. We have studied plasma CK in 206 pairs of twins and have analysed the results after separating them into what appear to be two Gaussian frequency distributions. The results in the main distribution (CK less than 300 iu/1) are apparently affected by genetic factors common to both men and women, and by environmental factors which are of much greater effect in men. The tendency for some men to have very high CK values may also have a genetic basis.
DATE PUBLISHED
1986
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1986/01/01
medline 1986/01/01 00:01
entrez 1986/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whitfield JB Whitfield J B JB
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 35
ISSUE: 1-2
TITLE: Acta geneticae medicae et gemellologiae
ISOABBREVIATION: Acta Genet Med Gemellol (Roma)
YEAR: 1986
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0001-5660
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Acta Genet Med Gemellol (Roma)
COUNTRY: ITALY
ISSNLINKING: 0001-5660
NLMUNIQUEID: 0370314
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Creatine Kinase genetics
Environment genetics
Female genetics
Genetic Variation genetics
Humans genetics
Male genetics
Sex Factors genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
EC 2.7.3.2 Creatine Kinase
OTHER ID's