Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
3461156
TITLE
The familial sporadic classification: its power for the resolution of genetic and environmental etiologic factors.
ABSTRACT
An increasingly popular research method for identifying etiologic heterogeneity in psychiatric illness has been to compare the frequency of a risk factor in affected individuals with no affected relatives (sporadic cases) and in affected individuals with one or more affected relatives (familial cases). This paper presents a power analysis of this familial vs sporadic method, assuming a multifactorial model with a normally distributed liability to illness resulting from the additive effect of polygenes and multiple environmental factors. Various parameter estimates for a risk factor that identifies a component of either the genetic or the environmental contribution to disease liability are examined. Almost without exception, large sample sizes of probands and relatives need to be studied to have a substantial probability of detecting etiologic heterogeneity. The required sample size decreases dramatically when monozygotic twins are studied. If the multifactorial model accurately depicts the etiology for psychiatric disorders, these results suggest that the familial versus sporadic design is useful only when pursued in the context of large sample nuclear family studies or studies of monozygotic twins.
DATE PUBLISHED
1986
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1986/01/01
medline 1986/01/01 00:01
entrez 1986/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Eaves LJ Eaves L J LJ
Kendler KS Kendler K S KS
Schulz SC 2nd Schulz S C SC
INVESTIGATORS
JOURNAL
VOLUME: 20
ISSUE: 2
TITLE: Journal of psychiatric research
ISOABBREVIATION: J Psychiatr Res
YEAR: 1986
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0022-3956
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: J Psychiatr Res
COUNTRY: England
ISSNLINKING: 0022-3956
NLMUNIQUEID: 0376331
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
GM30520 NIGMS NIH HHS United States
GM32732 NIGMS NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Diseases in Twins
Environment
Genetic Markers
Humans
Mental Disorders genetics
Models, Theoretical genetics
Research Design genetics
Risk genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Genetic Markers
OTHER ID's