Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
32546850
TITLE
Genetic aetiology of self-harm ideation and behaviour.
ABSTRACT
Family studies have identified a heritable component to self-harm that is partially independent from comorbid psychiatric disorders. However, the genetic aetiology of broad sense (non-suicidal and suicidal) self-harm has not been characterised on the molecular level. In addition, controversy exists about the degree to which suicidal and non-suicidal self-harm share a common genetic aetiology. In the present study, we conduct genome-wide association studies (GWAS) on lifetime self-harm ideation and self-harm behaviour (i.e. any lifetime self-harm act regardless of suicidal intent) using data from the UK Biobank (n > 156,000). We also perform genome wide gene-based tests and characterize the SNP heritability and genetic correlations between these traits. Finally, we test whether polygenic risk scores (PRS) for self-harm ideation and self-harm behaviour predict suicide attempt, suicide thoughts and non-suicidal self-harm (NSSH) in an independent target sample of 8,703 Australian adults. Our GWAS results identified one genome-wide significant locus associated with each of the two phenotypes. SNP heritability (h ) estimates were ~10%, and both traits were highly genetically correlated (LDSC r  > 0.8). Gene-based tests identified seven genes associated with self-harm ideation and four with self-harm behaviour. Furthermore, in the target sample, PRS for self-harm ideation were significantly associated with suicide thoughts and NSSH, and PRS for self-harm behaviour predicted suicide thoughts and suicide attempt. Follow up regressions identified a shared genetic aetiology between NSSH and suicide thoughts, and between suicide thoughts and suicide attempt. Evidence for shared genetic aetiology between NSSH and suicide attempt was not statistically significant.
DATE PUBLISHED
2020 Jun 16
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2020/01/14
accepted 2020/05/11
entrez 2020/06/18 06:00
pubmed 2020/06/18 06:00
medline 2020/06/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Campos AI Campos Adrian I AI Faculty of Medicine, The University of Queensland, Herston, QLD, Australia. adrian.campos@qimrberghofer.edu.au.
Verweij KJH Verweij Karin J H KJH Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands.
Statham DJ Statham Dixie J DJ Discipline of Psychology, School of Health and Life Sciences, Federation University, Ballarat, VIC, 3550, Australia.
Madden PAF Madden Pamela A F PAF Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA.
Maciejewski DF Maciejewski Dominique F DF Department of Developmental Psychopathology, Behavioural Science Institute, Nijmegen, the Netherlands.
Davis KAS Davis Katrina A S KAS South London and Maudsley NHS Foundation Trust, London, UK.
John A John Ann A HDRUK, Swansea University Medical School, Swansea, UK.
Hotopf M Hotopf Matthew M South London and Maudsley NHS Foundation Trust, London, UK.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University School of Medicine, St Louis, MO, 63110, USA.
Martin NG Martin Nicholas G NG Department of Genetics & Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Rentería ME Rentería Miguel E ME Faculty of Medicine, The University of Queensland, Herston, QLD, Australia. miguel.renteria@qimrberghofer.edu.au.
INVESTIGATORS
JOURNAL
VOLUME: 10
ISSUE: 1
TITLE: Scientific reports
ISOABBREVIATION: Sci Rep
YEAR: 2020
MONTH: Jun
DAY: 16
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2045-2322
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Sci Rep
COUNTRY: England
ISSNLINKING: 2045-2322
NLMUNIQUEID: 101563288
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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