Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
31802129
TITLE
Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes.
ABSTRACT
STUDY OBJECTIVES NlmCategory: OBJECTIVE
Sleep problems are common, serving as both a predictor and symptom of posttraumatic stress disorder (PTSD), with these bidirectional relationships well established in the literature. While both sleep phenotypes and PTSD are moderately heritable, there has been a paucity of investigation into potential genetic overlap between sleep and PTSD. Here, we estimate genetic correlations between multiple sleep phenotypes (including insomnia symptoms, sleep duration, daytime sleepiness, and chronotype) and PTSD, using results from the largest genome-wide association study (GWAS) to date of PTSD, as well as publicly available GWAS results for sleep phenotypes within UK Biobank data (23 variations, encompassing four main phenotypes).
METHODS NlmCategory: METHODS
Sleep problems are common, serving as both a predictor and symptom of posttraumatic stress disorder (PTSD), with these bidirectional relationships well established in the literature. While both sleep phenotypes and PTSD are moderately heritable, there has been a paucity of investigation into potential genetic overlap between sleep and PTSD. Here, we estimate genetic correlations between multiple sleep phenotypes (including insomnia symptoms, sleep duration, daytime sleepiness, and chronotype) and PTSD, using results from the largest genome-wide association study (GWAS) to date of PTSD, as well as publicly available GWAS results for sleep phenotypes within UK Biobank data (23 variations, encompassing four main phenotypes). Genetic correlations were estimated utilizing linkage disequilibrium score regression (LDSC), an approach that uses GWAS summary statistics to compute genetic correlations across traits, and Mendelian randomization (MR) analyses were conducted to follow up on significant correlations.
RESULTS NlmCategory: RESULTS
Sleep problems are common, serving as both a predictor and symptom of posttraumatic stress disorder (PTSD), with these bidirectional relationships well established in the literature. While both sleep phenotypes and PTSD are moderately heritable, there has been a paucity of investigation into potential genetic overlap between sleep and PTSD. Here, we estimate genetic correlations between multiple sleep phenotypes (including insomnia symptoms, sleep duration, daytime sleepiness, and chronotype) and PTSD, using results from the largest genome-wide association study (GWAS) to date of PTSD, as well as publicly available GWAS results for sleep phenotypes within UK Biobank data (23 variations, encompassing four main phenotypes). Genetic correlations were estimated utilizing linkage disequilibrium score regression (LDSC), an approach that uses GWAS summary statistics to compute genetic correlations across traits, and Mendelian randomization (MR) analyses were conducted to follow up on significant correlations. Significant, moderate genetic correlations were found between insomnia symptoms (rg range 0.36-0.49), oversleeping (rg range 0.32-0.44), undersleeping (rg range 0.48-0.49), and PTSD. In contrast, there were mixed results for continuous sleep duration and daytime sleepiness phenotypes, and chronotype was not correlated with PTSD. MR analyses did not provide evidence for casual effects of sleep phenotypes on PTSD.
CONCLUSION NlmCategory: CONCLUSIONS
Sleep problems are common, serving as both a predictor and symptom of posttraumatic stress disorder (PTSD), with these bidirectional relationships well established in the literature. While both sleep phenotypes and PTSD are moderately heritable, there has been a paucity of investigation into potential genetic overlap between sleep and PTSD. Here, we estimate genetic correlations between multiple sleep phenotypes (including insomnia symptoms, sleep duration, daytime sleepiness, and chronotype) and PTSD, using results from the largest genome-wide association study (GWAS) to date of PTSD, as well as publicly available GWAS results for sleep phenotypes within UK Biobank data (23 variations, encompassing four main phenotypes). Genetic correlations were estimated utilizing linkage disequilibrium score regression (LDSC), an approach that uses GWAS summary statistics to compute genetic correlations across traits, and Mendelian randomization (MR) analyses were conducted to follow up on significant correlations. Significant, moderate genetic correlations were found between insomnia symptoms (rg range 0.36-0.49), oversleeping (rg range 0.32-0.44), undersleeping (rg range 0.48-0.49), and PTSD. In contrast, there were mixed results for continuous sleep duration and daytime sleepiness phenotypes, and chronotype was not correlated with PTSD. MR analyses did not provide evidence for casual effects of sleep phenotypes on PTSD. Sleep phenotypes, particularly insomnia symptoms and extremes of sleep duration, have shared genetic etiology with PTSD, but causal relationships were not identified. This highlights the importance of further investigation into the overlapping influences on these phenotypes as sample sizes increase and new methods to investigate directionality and causality become available.
Sleep Research Society 2019. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com.
DATE PUBLISHED
2019 Dec 05
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2019/02/07
revised 2019/08/17
entrez 2019/12/06 06:00
pubmed 2019/12/06 06:00
medline 2019/12/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Lind MJ Lind Mackenzie J MJ Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA.
Brick LA Brick Leslie A LA Department of Psychiatry and Human Behavior in Alpert Medical School of Brown University, RI.
Gehrman PR Gehrman Philip R PR Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, PA.
Duncan LE Duncan Laramie E LE Department of Psychiatry and Behavioral Sciences, Stanford University, CA.
Gelaye B Gelaye Bizu B Departments of Epidemiology and Psychiatry, Harvard T. H. Chan School of Public Health and Harvard School of Medicine, MA.
Maihofer AX Maihofer Adam X AX Department of Psychiatry, University of California San Diego and Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, CA.
Nievergelt CM Nievergelt Caroline M CM Department of Psychiatry, University of California San Diego and Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, CA.
Nugent NR Nugent Nicole R NR Bradley/Hasbro Children's Research Center of Rhode Island Hospital, RI.
Stein MB Stein Murray B MB Departments of Psychiatry and Family Medicine & Public Health, University of California San Diego, CA and VA San Diego Healthcare System, CA.
Amstadter AB Amstadter Ananda B AB Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA.
Psychiatric Genomics Consortium Posttraumatic Stress Disorder
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Aiello Allison E AE
Almli Lynn M LM
Amstadter Ananda B AB
Andersen Søren B SB
Andreassen Ole A OA
Arbisi Paul A PA
Ashley-Koch Allison E AE
Atkinson Elizabeth G EG
Austin S Bryn SB
Avdibegovic Esmina E
Babić Dragan D
Bækvad-Hansen Marie M
Baker Dewleen G DG
Beckham Jean C JC
Bierut Laura J LJ
Bisson Jonathan I JI
Boks Marco P MP
Bolger Elizabeth A EA
Børglum Anders D AD
Bradley Bekh B
Brashear Megan M
Breen Gerome G
Bryant Richard A RA
Bustamante Angela C AC
Bybjerg-Grauholm Jonas J
Calabrese Joseph R JR
Caldas-de-Almeida José M JM
Chen Chia-Yen CY
Coleman Jonathan R I JRI
Dale Anders M AM
Dalvie Shareefa S
Daly Mark J MJ
Daskalakis Nikolaos P NP
Deckert Jürgen J
Delahanty Douglas L DL
Dennis Michelle F MF
Disner Seth G SG
Domschke Katharina K
Duncan Laramie E LE
Dzubur-Kulenovic Alma A
Erbes Christopher R CR
Evans Alexandra A
Farrer Lindsay A LA
Feeny Norah C NC
Flory Janine D JD
Forbes David D
Franz Carol E CE
Galea Sandro S
Garrett Melanie E ME
Gelaye Bizu B
Gelernter Joel J
Geuze Elbert E
Gillespie Charles C
Uka Aferdita Goci AG
Gordon Scott D SD
Guffanti Guia G
Haas Magali M
Hammamieh Rasha R
Hauser Michael A MA
Heath Andrew C AC
Hemmings Sian M J SMJ
Hougaard David Michael DM
Jakovljevic Miro M
Jett Marti M
Johnson Eric Otto EO
Jones Ian I
Jovanovic Tanja T
Junglen Angela G AG
Karstoft Karen-Inge KI
Kaufman Milissa L ML
Kessler Ronald C RC
Khan Alaptagin A
Kimbrel Nathan A NA
King Anthony P AP
Koen Nastassja N
Koenen Karestan C KC
Kranzler Henry R HR
Kremen William S WS
Lawford Bruce R BR
Lebois Lauren A M LAM
Lewis Catrin E CE
Liberzon Israel I
Linnstaedt Sarah D SD
Logue Mark W MW
Lori Adriana A
Lugonja Bozo B
Luykx Jurjen J JJ
Lyons Michael J MJ
Maihofer Adam X AX
Maples-Keller Jessica J
Marmar Charles C
Martin Nicholas G NG
Maurer Douglas D
Mavissakalian Matig R MR
McFarlane Alexander A
McGlinchey Regina E RE
McLaughlin Katie A KA
McLean Samuel A SA
McLeay Sarah S
Mehta Divya D
Milberg William P WP
Miller Mark W MW
Morey Rajendra A RA
Morris Charles Phillip CP
Mors Ole O
Mortensen Preben B PB
Nelson Elliot C EC
Nievergelt Caroline M CM
Nordentoft Merete M
Norman Sonya B SB
O'Donnell Meaghan M
Orcutt Holly K HK
Panizzon Matthew S MS
Peters Edward S ES
Peterson Alan L AL
Peverill Matthew M
Pietrzak Robert H RH
Polusny Melissa A MA
Qin Xue-Jun XJ
Ratanatharathorn Andrew A
Ressler Kerry J KJ
Rice John P JP
Risbrough Victoria B VB
Roberts Andrea L AL
Rothbaum Alex O AO
Rothbaum Barbara O BO
Roy-Byrne Peter P
Ruggiero Ken K
Rung Ariane A
Rutten Bart P F BPF
Saccone Nancy L NL
Sanchez Sixto E SE
Schijven Dick D
Seedat Soraya S
Seligowski Antonia V AV
Seng Julia S JS
Sheerin Christina M CM
Silove Derrick D
Smith Alicia K AK
Smoller Jordan W JW
Sponheim Scott R SR
Stein Dan J DJ
Stein Murray B MB
Stevens Jennifer S JS
Teicher Martin H MH
Thompson Wesley K WK
Torres Katy K
Trapido Edward E
Uddin Monica M
Ursano Robert J RJ
Heuvel Leigh Luella van den LLVD
Hooff Miranda van MV
Vermetten Eric E
Vinkers Christiaan H CH
Voisey Joanne J
Wang Yunpeng Y
Wang Zhewu Z
Werge Thomas T
Williams Michelle A MA
Williamson Douglas E DE
Winternitz Sherry S
Wolf Christiane C
Wolf Erika J EJ
Wolff Jonathan D JD
Yehuda Rachel R
Young Keith A KA
McD Young Ross R
Zhao Hongyu H
Zoellner Lori A LA
JOURNAL
VOLUME:
ISSUE:
TITLE: Sleep
ISOABBREVIATION: Sleep
YEAR: 2019
MONTH: Dec
DAY: 05
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1550-9109
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Sleep
COUNTRY: United States
ISSNLINKING: 0161-8105
NLMUNIQUEID: 7809084
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
LDSC
LDSR
endelian randomization
genetic correlation
genetics
insomnia
posttraumatic stress disorder
sleep and psychiatric conditions
sleep disorders
sleep duration
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's