Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
31599630
TITLE
Comparing the potential causal influence of two indicators of early alcohol use on later alcohol use disorder symptoms.
ABSTRACT
Age of first drink (AFD) has repeatedly been found to be associated with alcohol use disorder (AUD); however, some studies suggest this is a noncausal effect that may be due to childhood risk factors or familial influences. In contrast to indicators of any early alcohol use, such as AFD, indicators of a pattern of repeated drinking may be more likely to be causally associated with later problematic alcohol use. The current study examined AFD and age of onset of regular drinking (ARD; defined as drinking at least once a month for 6 or more months) as quasicausal predictors of lifetime AUD symptoms. Participants were 3,005 adult Australian twins who reported having been regular drinkers in their lifetime. Semistructured interviews were conducted to assess AFD, ARD, AUD, externalizing symptomatology, and other substance use. Personality traits were assessed via questionnaire. Unadjusted and adjusted multilevel discordant twin models were conducted using data from 1,041 complete twin pairs; adjusted models included socioeconomic status, personality, conduct disorder, and early initiation of regular smoking and marijuana use as covariates. Results from fully adjusted models controlling for familial confounds provided evidence for a causal influence of ARD on AUD symptoms, whereby twins with an earlier age of regular drinking than their cotwin had more lifetime AUD symptoms. However, AFD did not significantly predict AUD symptoms after adjusting for confounds. These results suggest that early regular drinking may serve as a causal risk factor for future problems, while early initiation of any alcohol use may indicate genetic liability. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
DATE PUBLISHED
2020 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
pmc-release 2021/04/01
pubmed 2019/10/11 06:00
medline 2019/10/11 06:00
entrez 2019/10/11 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Davis CN Davis Christal N CN Department of Psychological Sciences.
Slutske WS Slutske Wendy S WS Department of Psychological Sciences.
Piasecki TM Piasecki Thomas M TM Department of Psychological Sciences.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute.
Lynskey MT Lynskey Michael T MT Institute of Psychiatry, King's College London.
INVESTIGATORS
JOURNAL
VOLUME: 129
ISSUE: 3
TITLE: Journal of abnormal psychology
ISOABBREVIATION: J Abnorm Psychol
YEAR: 2020
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1939-1846
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Abnorm Psychol
COUNTRY: United States
ISSNLINKING: 0021-843X
NLMUNIQUEID: 0034461
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01 DA018267 NIDA NIH HHS United States
T32 AA013526 NIAAA NIH HHS United States
NIH HHS United States
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