Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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31594949
TITLE
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.
ABSTRACT
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5-20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson's disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations.
DATE PUBLISHED
2019 10 08
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2019/07/25
accepted 2019/09/18
entrez 2019/10/10 06:00
pubmed 2019/10/09 06:00
medline 2020/02/20 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Nievergelt CM Nievergelt Caroline M CM Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA. cnievergelt@ucsd.edu.
Maihofer AX Maihofer Adam X AX Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA.
Klengel T Klengel Torsten T University Medical Center Goettingen, Department of Psychiatry, Göttingen, DE, Germany.
Atkinson EG Atkinson Elizabeth G EG Massachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA.
Chen CY Chen Chia-Yen CY Massachusetts General Hospital, Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Boston, MA, USA.
Choi KW Choi Karmel W KW Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
Coleman JRI Coleman Jonathan R I JRI King's College London, NIHR BRC at the Maudsley, London, GB, USA.
Dalvie S Dalvie Shareefa S University of Cape Town, SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Cape Town, Western Cape, ZA, USA.
Duncan LE Duncan Laramie E LE Stanford University, Department of Psychiatry and Behavioral Sciences, Stanford, CA, USA.
Gelernter J Gelernter Joel J VA Connecticut Healthcare Center, West Haven, CT, USA.
Levey DF Levey Daniel F DF Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.
Logue MW Logue Mark W MW VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.
Polimanti R Polimanti Renato R Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.
Provost AC Provost Allison C AC Cohen Veterans Bioscience, Cambridge, MA, USA.
Ratanatharathorn A Ratanatharathorn Andrew A Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
Stein MB Stein Murray B MB Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA.
Torres K Torres Katy K Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA.
Aiello AE Aiello Allison E AE Gillings School of Global Public Health, Department of Epidemiology, Chapel Hill, NC, USA.
Almli LM Almli Lynn M LM Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Amstadter AB Amstadter Ananda B AB Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA.
Andersen SB Andersen Søren B SB The Danish Veteran Centre, Research and Knowledge Centre, Ringsted, Sjaelland, Denmark.
Andreassen OA Andreassen Ole A OA University of Oslo, Institute of Clinical Medicine, Oslo, NO, Norway.
Arbisi PA Arbisi Paul A PA Minneapolis VA Health Care System, Mental Health Service Line, Minneapolis, MN, USA.
Ashley-Koch AE Ashley-Koch Allison E AE Duke University, Duke Molecular Physiology Institute, Durham, NC, USA.
Austin SB Austin S Bryn SB Harvard School of Public Health, Department of Social and Behavioral Sciences, Boston, MA, USA.
Avdibegovic E Avdibegovic Esmina E University Clinical Center of Tuzla, Department of Psychiatry, Tuzla, BA, Bosnia and Herzegovina.
Babić D Babić Dragan D University Clinical Center of Mostar, Department of Psychiatry, Mostar, BA, Bosnia and Herzegovina.
Bækvad-Hansen M Bækvad-Hansen Marie M The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK, Denmark.
Baker DG Baker Dewleen G DG Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA.
Beckham JC Beckham Jean C JC VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), Genetics Research Laboratory, Durham, NC, USA.
Bierut LJ Bierut Laura J LJ Washington University in Saint Louis School of Medicine, Department of Psychiatry, Saint Louis, MO, USA.
Bisson JI Bisson Jonathan I JI Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, UK.
Boks MP Boks Marco P MP UMC Utrecht Brain Center Rudolf Magnus, Department of Translational Neuroscience, Utrecht, Utrecht, NL, Netherlands.
Bolger EA Bolger Elizabeth A EA McLean Hospital, Belmont, MA, USA.
Børglum AD Børglum Anders D AD Aarhus University, Department of Biomedicine - Human Genetics, Aarhus, DK, Denmark.
Bradley B Bradley Bekh B Atlanta VA Health Care System, Mental Health Service Line, Decatur, GA, USA.
Brashear M Brashear Megan M Louisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology, New Orleans, LA, USA.
Breen G Breen Gerome G King's College London, NIHR BRC at the Maudsley, London, GB, USA.
Bryant RA Bryant Richard A RA University of New South Wales, Department of Psychology, Sydney, NSW, Australia.
Bustamante AC Bustamante Angela C AC University of Michigan Medical School, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ann Arbor, MI, USA.
Bybjerg-Grauholm J Bybjerg-Grauholm Jonas J The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK, Denmark.
Calabrese JR Calabrese Joseph R JR University Hospitals, Department of Psychiatry, Cleveland, OH, USA.
Caldas-de-Almeida JM Caldas-de-Almeida José M JM CEDOC -Chronic Diseases Research Centre, Lisbon Institute of Global Mental Health, Lisbon, PT, Portugal.
Dale AM Dale Anders M AM University of California San Diego, Department of Radiology, Department of Neurosciences, La Jolla, CA, USA.
Daly MJ Daly Mark J MJ Massachusetts General Hospital, Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Boston, MA, USA.
Daskalakis NP Daskalakis Nikolaos P NP Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, USA.
Deckert J Deckert Jürgen J University Hospital of Würzburg, Center of Mental Health, Psychiatry, Psychosomatics and Psychotherapy, Würzburg, DE, Germany.
Delahanty DL Delahanty Douglas L DL Kent State University, Research and Sponsored Programs, Kent, OH, USA.
Dennis MF Dennis Michelle F MF VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), Genetics Research Laboratory, Durham, NC, USA.
Disner SG Disner Seth G SG Minneapolis VA Health Care System, Research Service Line, Minneapolis, MN, USA.
Domschke K Domschke Katharina K University of Freiburg, Faculty of Medicine, Centre for Basics in Neuromodulation, Freiburg, DE, Germany.
Dzubur-Kulenovic A Dzubur-Kulenovic Alma A University Clinical Center of Sarajevo, Department of Psychiatry, Sarajevo, BA, Bosnia and Herzegovina.
Erbes CR Erbes Christopher R CR Minneapolis VA Health Care System, Center for Care Delivery and Outcomes Research (CCDOR), Minneapolis, MN, USA.
Evans A Evans Alexandra A Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, South Glamorgan, GB, USA.
Farrer LA Farrer Lindsay A LA Boston University School of Medicine, Department of Medicine, Boston, MA, USA.
Feeny NC Feeny Norah C NC Case Western Reserve University, Department of Psychological Sciences, Cleveland, OH, USA.
Flory JD Flory Janine D JD Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, USA.
Forbes D Forbes David D University of Melbourne, Department of Psychiatry, Melbourne, VIC, AU, USA.
Franz CE Franz Carol E CE University of California San Diego, Department of Psychiatry, La Jolla, CA, USA.
Galea S Galea Sandro S Boston University, Department of Psychological and Brain Sciences, Boston, MA, USA.
Garrett ME Garrett Melanie E ME Duke University, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA.
Gelaye B Gelaye Bizu B Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
Geuze E Geuze Elbert E UMC Utrecht Brain Center Rudolf Magnus, Department of Psychiatry, Utrecht, Utrecht, NL, Netherlands.
Gillespie C Gillespie Charles C Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Uka AG Uka Aferdita Goci AG University Clinical Centre of Kosovo, Department of Psychiatry, Prishtina, Kosovo, XK, USA.
Gordon SD Gordon Scott D SD QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, Queensland, Australia.
Guffanti G Guffanti Guia G McLean Hospital, Belmont, MA, USA.
Hammamieh R Hammamieh Rasha R US Army Medical Research and Materiel Command, USACEHR, Fort Detrick, MD, USA.
Harnal S Harnal Supriya S Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Hauser MA Hauser Michael A MA Duke University, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA.
Heath AC Heath Andrew C AC Washington University in Saint Louis School of Medicine, Department of Genetics, Saint Louis, MO, USA.
Hemmings SMJ Hemmings Sian M J SMJ Stellenbosch University Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA, South Africa.
Hougaard DM Hougaard David Michael DM The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DK, Denmark.
Jakovljevic M Jakovljevic Miro M University Hospital Center of Zagreb, Department of Psychiatry, Zagreb, HR, USA.
Jett M Jett Marti M US Army Medical Research and Materiel Command, USACEHR, Fort Detrick, MD, USA.
Johnson EO Johnson Eric Otto EO RTI International, Behavioral Health and Criminal Justice Division, Research Triangle Park, NC, USA.
Jones I Jones Ian I Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, South Glamorgan, GB, USA.
Jovanovic T Jovanovic Tanja T Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Qin XJ Qin Xue-Jun XJ Duke University, Duke Molecular Physiology Institute, Durham, NC, USA.
Junglen AG Junglen Angela G AG Kent State University, Department of Psychological Sciences, Kent, OH, USA.
Karstoft KI Karstoft Karen-Inge KI University of Copenhagen, Department of Psychology, Copenhagen, DK, Denmark.
Kaufman ML Kaufman Milissa L ML McLean Hospital, Belmont, MA, USA.
Kessler RC Kessler Ronald C RC Harvard Medical School, Department of Psychiatry, Boston, MA, USA.
Khan A Khan Alaptagin A Harvard Medical School, Department of Health Care Policy, Boston, MA, USA.
Kimbrel NA Kimbrel Nathan A NA VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), Genetics Research Laboratory, Durham, NC, USA.
King AP King Anthony P AP University of Michigan Medical School, Department of Psychiatry, Ann Arbor, MI, USA.
Koen N Koen Nastassja N University of Cape Town, SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Cape Town, Western Cape, ZA, USA.
Kranzler HR Kranzler Henry R HR Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.
Kremen WS Kremen William S WS Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Lawford BR Lawford Bruce R BR Queensland University of Technology, School of Biomedical Sciences, Kelvin Grove, QLD, AU, Australia.
Lebois LAM Lebois Lauren A M LAM McLean Hospital, Belmont, MA, USA.
Lewis CE Lewis Catrin E CE Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, South Glamorgan, GB, USA.
Linnstaedt SD Linnstaedt Sarah D SD UNC Institute for Trauma Recovery, Department of Anesthesiology, Chapel Hill, NC, USA.
Lori A Lori Adriana A Emory University, Department of Gynecology and Obstetrics, Atlanta, GA, USA.
Lugonja B Lugonja Bozo B Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, South Glamorgan, GB, USA.
Luykx JJ Luykx Jurjen J JJ UMC Utrecht Brain Center Rudolf Magnus, Department of Psychiatry, Utrecht, Utrecht, NL, Netherlands.
Lyons MJ Lyons Michael J MJ Boston University, Dean's Office, Boston, MA, USA.
Maples-Keller J Maples-Keller Jessica J Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Marmar C Marmar Charles C New York University School of Medicine, Department of Psychiatry, New York, NY, USA.
Martin AR Martin Alicia R AR Massachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, Queensland, Australia.
Maurer D Maurer Douglas D United States Army, Command, Fort Sill, OK, USA.
Mavissakalian MR Mavissakalian Matig R MR University Hospitals, Department of Psychiatry, Cleveland, OH, USA.
McFarlane A McFarlane Alexander A University of Adelaide, Department of Psychiatry, Adelaide, South Australia, AU, Australia.
McGlinchey RE McGlinchey Regina E RE VA Boston Health Care System, GRECC/TRACTS, Boston, MA, USA.
McLaughlin KA McLaughlin Katie A KA Harvard University, Department of Psychology, Boston, MA, USA.
McLean SA McLean Samuel A SA UNC Institute for Trauma Recovery, Department of Emergency Medicine, Chapel Hill, NC, USA.
McLeay S McLeay Sarah S Gallipoli Medical Research Institute, PTSD Initiative, Greenslopes, Queensland, AU, Australia.
Mehta D Mehta Divya D Queensland University of Technology, School of Psychology and Counseling, Faculty of Health, Kelvin Grove, QLD, AU, Australia.
Milberg WP Milberg William P WP VA Boston Health Care System, GRECC/TRACTS, Boston, MA, USA.
Miller MW Miller Mark W MW VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.
Morey RA Morey Rajendra A RA Duke University, Duke Molecular Physiology Institute, Durham, NC, USA.
Morris CP Morris Charles Phillip CP Queensland University of Technology, School of Biomedical Sciences, Kelvin Grove, QLD, AU, Australia.
Mors O Mors Ole O Aarhus University Hospital, Psychosis Research Unit, Risskov, DK, Denmark.
Mortensen PB Mortensen Preben B PB Aarhus University, National Centre for Register-Based Research, Aarhus, DK, Denmark.
Neale BM Neale Benjamin M BM Massachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA.
Nelson EC Nelson Elliot C EC Washington University in Saint Louis School of Medicine, Department of Psychiatry, Saint Louis, MO, USA.
Nordentoft M Nordentoft Merete M University of Copenhagen, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, Copenhagen, DK, Denmark.
Norman SB Norman Sonya B SB National Center for Post Traumatic Stress Disorder, Executive Division, White River Junction, San Diego, VT, USA.
O'Donnell M O'Donnell Meaghan M University of Melbourne, Department of Psychiatry, Melbourne, VIC, AU, USA.
Orcutt HK Orcutt Holly K HK Northern Illinois University, Department of Psychology, DeKalb, IL, USA.
Panizzon MS Panizzon Matthew S MS University of California San Diego, Department of Psychiatry, La Jolla, CA, USA.
Peters ES Peters Edward S ES Louisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology, New Orleans, LA, USA.
Peterson AL Peterson Alan L AL University of Texas Health Science Center at San Antonio, Department of Psychiatry, San Antonio, TX, USA.
Peverill M Peverill Matthew M University of Washington, Department of Psychology, Seattle, WA, USA.
Pietrzak RH Pietrzak Robert H RH U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, West Haven, CT, USA.
Polusny MA Polusny Melissa A MA Minneapolis VA Health Care System, Department of Psychology, Minneapolis, MN, USA.
Rice JP Rice John P JP Washington University in Saint Louis School of Medicine, Department of Psychiatry, Saint Louis, MO, USA.
Ripke S Ripke Stephan S Charité - Universitätsmedizin, Department of Psychiatry and Psychotherapy, Berlin, GE, Germany.
Risbrough VB Risbrough Victoria B VB Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA.
Roberts AL Roberts Andrea L AL Harvard T.H. Chan School of Public Health, Department of Environmental Health, Boston, MA, USA.
Rothbaum AO Rothbaum Alex O AO Case Western Reserve University, Department of Psychological Sciences, Cleveland, OH, USA.
Rothbaum BO Rothbaum Barbara O BO Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Roy-Byrne P Roy-Byrne Peter P University of Washington, Department of Psychology, Seattle, WA, USA.
Ruggiero K Ruggiero Ken K Medical University of South Carolina, Department of Nursing and Department of Psychiatry, Charleston, SC, USA.
Rung A Rung Ariane A Louisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology, New Orleans, LA, USA.
Rutten BPF Rutten Bart P F BPF Maastricht Universitair Medisch Centrum, School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht, Limburg, NL, Netherlands.
Saccone NL Saccone Nancy L NL Washington University in Saint Louis School of Medicine, Department of Psychiatry, Saint Louis, MO, USA.
Sanchez SE Sanchez Sixto E SE Universidad Peruana de Ciencias Aplicadas Facultad de Ciencias de la Salud, Department of Medicine, Lima, Lima, PE, USA.
Schijven D Schijven Dick D UMC Utrecht Brain Center Rudolf Magnus, Department of Psychiatry, Utrecht, Utrecht, NL, Netherlands.
Seedat S Seedat Soraya S Stellenbosch University Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA, South Africa.
Seligowski AV Seligowski Antonia V AV McLean Hospital, Belmont, MA, USA.
Seng JS Seng Julia S JS University of Michigan, School of Nursing, Ann Arbor, MI, USA.
Sheerin CM Sheerin Christina M CM Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA.
Silove D Silove Derrick D University of New South Wales, Department of Psychiatry, Sydney, NSW, AU, USA.
Smith AK Smith Alicia K AK Emory University, Department of Gynecology and Obstetrics, Atlanta, GA, USA.
Smoller JW Smoller Jordan W JW Massachusetts General Hospital, Department of Psychiatry, Boston, MA, USA.
Sponheim SR Sponheim Scott R SR University of Minnesota, Department of Psychiatry, Minneapolis, MN, USA.
Stein DJ Stein Dan J DJ University of Cape Town, SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Cape Town, Western Cape, ZA, USA.
Stevens JS Stevens Jennifer S JS Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Sumner JA Sumner Jennifer A JA Columbia University Medical Center, Department of Medicine, New York, NY, USA.
Teicher MH Teicher Martin H MH McLean Hospital, Belmont, MA, USA.
Thompson WK Thompson Wesley K WK Oslo University Hospital, KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo, NO, USA.
Trapido E Trapido Edward E Louisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology, New Orleans, LA, USA.
Uddin M Uddin Monica M University of South Florida College of Public Health, Genomics Program, Tampa, FL, USA.
Ursano RJ Ursano Robert J RJ Uniformed Services University, Department of Psychiatry, Bethesda, Maryland, USA.
van den Heuvel LL van den Heuvel Leigh Luella LL Stellenbosch University Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA, South Africa.
Van Hooff M Van Hooff Miranda M University of Adelaide, Department of Psychiatry, Adelaide, South Australia, AU, Australia.
Vermetten E Vermetten Eric E Netherlands Defense Department, Research Center, Utrecht, UT, Netherlands.
Vinkers CH Vinkers Christiaan H CH Amsterdam UMC (location VUmc), Department of Psychiatry, Amsterdam, Holland, NL, Netherlands.
Voisey J Voisey Joanne J Queensland University of Technology, School of Biomedical Sciences, Kelvin Grove, QLD, AU, Australia.
Wang Y Wang Yunpeng Y Oslo University Hospital, KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo, NO, USA.
Wang Z Wang Zhewu Z Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston, SC, USA.
Werge T Werge Thomas T University of Copenhagen, Department of Clinical Medicine, Copenhagen, Denmark.
Williams MA Williams Michelle A MA Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
Williamson DE Williamson Douglas E DE Duke University, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA.
Winternitz S Winternitz Sherry S McLean Hospital, Belmont, MA, USA.
Wolf C Wolf Christiane C University Hospital of Würzburg, Center of Mental Health, Psychiatry, Psychosomatics and Psychotherapy, Würzburg, DE, Germany.
Wolf EJ Wolf Erika J EJ VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.
Wolff JD Wolff Jonathan D JD McLean Hospital, Belmont, MA, USA.
Yehuda R Yehuda Rachel R James J Peters VA Medical Center, Department of Mental Health, Bronx, NY, USA.
Young RM Young Ross McD RM Queensland University of Technology, School of Psychology and Counseling, Faculty of Health, Kelvin Grove, QLD, AU, Australia.
Young KA Young Keith A KA CTVHCS, COE for Research on Returning War Veterans, Waco, TX, USA.
Zhao H Zhao Hongyu H Yale University, Department of Biostatistics, New Haven, CT, USA.
Zoellner LA Zoellner Lori A LA University of Washington, Department of Psychiatry and Behavioral Sciences, Seattle, WA, USA.
Liberzon I Liberzon Israel I University of Michigan Medical School, Department of Psychiatry, Ann Arbor, MI, USA.
Ressler KJ Ressler Kerry J KJ Emory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA.
Haas M Haas Magali M Cohen Veterans Bioscience, Cambridge, MA, USA.
Koenen KC Koenen Karestan C KC Harvard School of Public Health, Department of Epidemiology, Boston, MA, USA.
INVESTIGATORS
JOURNAL
VOLUME: 10
ISSUE: 1
TITLE: Nature communications
ISOABBREVIATION: Nat Commun
YEAR: 2019
MONTH: 10
DAY: 08
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2041-1723
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Commun
COUNTRY: England
ISSNLINKING: 2041-1723
NLMUNIQUEID: 101528555
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01 MD011728 NIMHD NIH HHS United States
F32 MH109274 NIMH NIH HHS United States
IK2 RX002922 RRD VA United States
R21 MH112956 NIMH NIH HHS United States
IK1 RX002325 RRD VA United States
U01 MH109536 NIMH NIH HHS United States
R01 MH106595 NIMH NIH HHS United States
K01 MH118467 NIMH NIH HHS United States
MR/L010305/1 Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
African Continental Ancestry Group genetics
Datasets as Topic genetics
European Continental Ancestry Group genetics
Female genetics
Genetic Loci genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study genetics
Humans genetics
Male genetics
Sex Factors genetics
Stress Disorders, Post-Traumatic genetics
Ubiquitin-Protein Ligases genetics
Veterans statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
EC 2.3.2.27 Ubiquitin-Protein Ligases
EC 2.3.2.27 parkin protein
OTHER ID's