Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
31364586
TITLE
The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins.
ABSTRACT
The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.
DATE PUBLISHED
2019 12
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2019/08/01 06:00
medline 2019/08/01 06:00
entrez 2019/08/01 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Silventoinen K Silventoinen K K Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Jelenkovic A Jelenkovic A A Department of Public Health, University of Helsinki, Helsinki, Finland.
Yokoyama Y Yokoyama Y Y Department of Public Health Nursing, Osaka City University, Osaka, Japan.
Sund R Sund R R Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Sugawara M Sugawara M M Department of Psychology, Ochanomizu University, Tokyo, Japan.
Tanaka M Tanaka M M Center for Forensic Mental Health, Chiba University, Chiba, Japan.
Matsumoto S Matsumoto S S Institute for Education and Human Development, Ochanomizu University, Tokyo, Japan.
Bogl LH Bogl L H LH Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Freitas DL Freitas D L DL CIFI2D, Faculty of Sport, University of Porto, Porto, Portugal.
Maia JA Maia J A JA CIFI2D, Faculty of Sport, University of Porto, Porto, Portugal.
Hjelmborg JVB Hjelmborg J V B JVB The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark Odense, Denmark.
Aaltonen S Aaltonen S S Institute for Molecular Medicine Finland FIMM, Helsinki, Finland.
Piirtola M Piirtola M M Institute for Molecular Medicine Finland FIMM, Helsinki, Finland.
Latvala A Latvala A A Institute for Molecular Medicine Finland FIMM, Helsinki, Finland.
Calais-Ferreira L Calais-Ferreira L L Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Oliveira VC Oliveira V C VC Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil.
Ferreira PH Ferreira P H PH Musculoskeletal Health Research Group, Faculty of Health Sciences, The University of Sydney, Sydney, Australia.
Ji F Ji F F Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Ning F Ning F F Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Pang Z Pang Z Z Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Ordoñana JR Ordoñana J R JR IMIB-Arrixaca, Murcia, Spain.
Sánchez-Romera JF Sánchez-Romera J F JF IMIB-Arrixaca, Murcia, Spain.
Colodro-Conde L Colodro-Conde L L QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Burt SA Burt S A SA Michigan State University, East Lansing, MI, USA.
Klump KL Klump K L KL Michigan State University, East Lansing, MI, USA.
Martin NG Martin N G NG QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Medland SE Medland S E SE QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Montgomery GW Montgomery G W GW Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Kandler C Kandler C C Department of Psychology, University of Bremen, Bremen, Germany.
McAdams TA McAdams T A TA Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Eley TC Eley T C TC Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Gregory AM Gregory A M AM Department of Psychology, Goldsmiths, University of London, London, UK.
Saudino KJ Saudino K J KJ Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Dubois L Dubois L L School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Boivin M Boivin M M École de psychologie, Université Laval, Québec, Canada.
Brendgen M Brendgen M M Département de Psychologie, Université du Québec à Montréal, Montréal, Québec, Canada.
Dionne G Dionne G G École de psychologie, Université Laval, Québec, Canada.
Vitaro F Vitaro F F École de Psychoéducation, Université de Montréal, Montréal, Québec, Canada.
Tarnoki AD Tarnoki A D AD Hungarian Twin Registry, Budapest, Hungary.
Tarnoki DL Tarnoki D L DL Hungarian Twin Registry, Budapest, Hungary.
Haworth CMA Haworth C M A CMA MRC Integrative Epidemiology Unit, University of Bristol, Bristol, U.K.
Plomin R Plomin R R Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Öncel SY Öncel S Y SY Department of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey.
Aliev F Aliev F F Faculty of Business, Karabuk University, Turkey.
Medda E Medda E E Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health, Rome, Italy.
Nisticò L Nisticò L L Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health, Rome, Italy.
Toccaceli V Toccaceli V V Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health, Rome, Italy.
Craig JM Craig J M JM Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
Saffery R Saffery R R Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
Siribaddana SH Siribaddana S H SH Faculty of Medicine & Allied Sciences, Rajarata University of Sri Lanka Saliyapura, Sri Lanka.
Hotopf M Hotopf M M South London and Maudsley NHS Foundation Trust, London, UK.
Sumathipala A Sumathipala A A Research Institute for Primary Care and Health Sciences, School for Primary Care Research (SPCR), Faculty of Health, Keele University, Staffordshire, UK.
Rijsdijk F Rijsdijk F F Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Jeong HU Jeong H-U HU Department of Education, Mokpo National University, Jeonnam, South Korea.
Spector T Spector T T Department of Twin Research and Genetic Epidemiology, King's College, London, UK.
Mangino M Mangino M M NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.
Lachance G Lachance G G Department of Twin Research and Genetic Epidemiology, King's College, London, UK.
Gatz M Gatz M M Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Butler DA Butler D A DA Health and Medicine Division, The National Academies of Sciences, Engineering, and Medicine, Washington, DC, USA.
Gao W Gao W W Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Yu C Yu C C Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Li L Li L L Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Bayasgalan G Bayasgalan G G Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia.
Narandalai D Narandalai D D Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Harden KP Harden K P KP Department of Psychology, University of Texas at Austin, Austin, TX, USA.
Tucker-Drob EM Tucker-Drob E M EM Department of Psychology, University of Texas at Austin, Austin, TX, USA.
Christensen K Christensen K K Department of Clinical Biochemistry and Pharmacology and Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Skytthe A Skytthe A A The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark Odense, Denmark.
Kyvik KO Kyvik K O KO Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.
Derom CA Derom C A CA Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium.
Vlietinck RF Vlietinck R F RF Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Loos RJF Loos R J F RJF The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cozen W Cozen W W USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Hwang AE Hwang A E AE USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Mack TM Mack T M TM USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
He M He M M Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia.
Ding X Ding X X State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Silberg JL Silberg J L JL Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Maes HH Maes H H HH Department of Human and Molecular Genetics, Psychiatry & Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Cutler TL Cutler T L TL Twins Research Australia, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Australia.
Hopper JL Hopper J L JL Department of Epidemiology, School of Public Health, Seoul National University, Seoul, Korea.
Magnusson PKE Magnusson P K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Pedersen NL Pedersen N L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Dahl Aslan AK Dahl Aslan A K AK Institute of Gerontology and Aging Research Network - Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden.
Baker LA Baker L A LA Department of Psychology, University of Southern California, Los Angeles, CA, USA.
Tuvblad C Tuvblad C C School of Law, Psychology and Social Work, Örebro University, Sweden.
Bjerregaard-Andersen M Bjerregaard-Andersen M M Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Beck-Nielsen H Beck-Nielsen H H Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Sodemann M Sodemann M M Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.
Ullemar V Ullemar V V Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Almqvist C Almqvist C C Pediatric Allergy and Pulmonology Unit at Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Tan Q Tan Q Q Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Zhang D Zhang D D Department of Public Health, Qingdao University Medical College, Qingdao, China.
Swan GE Swan G E GE Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Krasnow R Krasnow R R Center for Health Sciences, SRI International, Menlo Park, CA, USA.
Jang KL Jang K L KL Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Knafo-Noam A Knafo-Noam A A The Hebrew University of Jerusalem, Jerusalem, Israel.
Mankuta D Mankuta D D Hadassah Hospital Obstetrics and Gynecology Department, Hebrew University Medical School, Jerusalem, Israel.
Abramson L Abramson L L The Hebrew University of Jerusalem, Jerusalem, Israel.
Lichtenstein P Lichtenstein P P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Krueger RF Krueger R F RF Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
McGue M McGue M M Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Pahlen S Pahlen S S Department of Psychology, University of California, Riverside, Riverside, CA, USA.
Tynelius P Tynelius P P Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Rasmussen F Rasmussen F F Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Duncan GE Duncan G E GE Washington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA.
Buchwald D Buchwald D D Washington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA.
Corley RP Corley R P RP Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.
Huibregtse BM Huibregtse B M BM Institute of Behavioral Science, University of Colorado, Boulder, CO, USA.
Nelson TL Nelson T L TL Department of Health and Exercise Sciences and Colorado School of Public Health, Colorado State University, Fort Collins, CO, USA.
Whitfield KE Whitfield K E KE Psychology and Neuroscience, Duke University, Durham, NC, USA.
Franz CE Franz C E CE Department of Psychiatry, University of California, San Diego, CA, USA.
Kremen WS Kremen W S WS VA San Diego Center of Excellence for Stress and Mental Health, La Jolla, CA, USA.
Lyons MJ Lyons M J MJ Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Ooki S Ooki S S Department of Health Science, Ishikawa Prefectural Nursing University, Kahoku, Ishikawa, Japan.
Brandt I Brandt I I Division of Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.
Nilsen TS Nilsen T S TS Division of Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.
Harris JR Harris J R JR Division of Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.
Sung J Sung J J Institute of Health and Environment, Seoul National University, Seoul, South-Korea.
Park HA Park H A HA Department of Health Science, School of Public Health Seoul National University, Seoul, South Korea.
Lee J Lee J J Department of Epidemiology, School of Public Health, Seoul National University, Seoul, Korea.
Lee SJ Lee S J SJ Institute of Health & Environment, Seoul National University, South Korea.
Willemsen G Willemsen G G Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, Netherlands.
Bartels M Bartels M M Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, Netherlands.
van Beijsterveldt CEM van Beijsterveldt C E M CEM Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, Netherlands.
Llewellyn CH Llewellyn C H CH Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Fisher A Fisher A A Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Rebato E Rebato E E Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Busjahn A Busjahn A A HealthTwiSt GmbH, Berlin, Germany.
Tomizawa R Tomizawa R R Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Inui F Inui F F Faculty of Health Science, Kio University, Nara, Japan.
Watanabe M Watanabe M M Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Honda C Honda C C Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Sakai N Sakai N N Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Hur YM Hur Y-M YM Department of Education, Mokpo National University, Jeonnam, South Korea.
Sørensen TIA Sørensen T I A TIA Department of Public Health (Section of Epidemiology), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Boomsma DI Boomsma D I DI Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, Netherlands.
Kaprio J Kaprio J J Institute for Molecular Medicine Finland FIMM, Helsinki, Finland.
INVESTIGATORS
JOURNAL
VOLUME: 22
ISSUE: 6
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2019
MONTH: 12
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R21 AG039572 NIA NIH HHS United States
R01 HD068435 NICHD NIH HHS United States
R01 MH062375 NIMH NIH HHS United States
R01 ES015150 NIEHS NIH HHS United States
R01 AG013662 NIA NIH HHS United States
T32 DA017637 NIDA NIH HHS United States
T32 AG052371 NIA NIH HHS United States
P01 AG008761 NIA NIH HHS United States
C1418/A7974 Cancer Research UK United Kingdom
G81/343 Medical Research Council United Kingdom
G120/635 Medical Research Council United Kingdom
MR/M021475/1 Medical Research Council United Kingdom
Department of Health United Kingdom
R01 AG053217 NIA NIH HHS United States
R01 MH081813 NIMH NIH HHS United States
R01 MH092377 NIMH NIH HHS United States
R21 MH070542 NIMH NIH HHS United States
R03 MH063851 NIMH NIH HHS United States
R01 MH118848 NIMH NIH HHS United States
R01 HD066040 NICHD NIH HHS United States
Wellcome Trust United Kingdom
CIHR Canada
G0901245 Medical Research Council United Kingdom
31/D19086 Biotechnology and Biological Sciences Research Council United Kingdom
R01 HD083613 NICHD NIH HHS United States
R01 MH058354 NIMH NIH HHS United States
RC2 HL103416 NHLBI NIH HHS United States
R01 AG018384 NIA NIH HHS United States
R01 AG018386 NIA NIH HHS United States
R01 AG022381 NIA NIH HHS United States
R01 AG022982 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
BMI
Twins
birth size
education
height
heritability
international comparisons
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's