Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
31313399
TITLE
Genetic and environmental risk factors in the non-medical use of over-the-counter or prescribed analgesics, and their relationship to major classes of licit and illicit substance use and misuse in a population-based sample of young adult twins.
ABSTRACT
BACKGROUND AND AIMS NlmCategory: OBJECTIVE
The non-medical use of over-the-counter or prescribed analgesics (NMUA) is a significant public health problem. Little is known about the genetic and environmental etiology of NMUA and how these risks relate to other classes of substance use and misuse. Our aims were to estimate the heritability NMUA and sources of genetic and environmental covariance with cannabis and nicotine use, cannabis and alcohol use disorders and nicotine dependence in Australian twins.
DESIGN NlmCategory: METHODS
The non-medical use of over-the-counter or prescribed analgesics (NMUA) is a significant public health problem. Little is known about the genetic and environmental etiology of NMUA and how these risks relate to other classes of substance use and misuse. Our aims were to estimate the heritability NMUA and sources of genetic and environmental covariance with cannabis and nicotine use, cannabis and alcohol use disorders and nicotine dependence in Australian twins. Biometrical genetic analyses or twin methods using structural equation univariate and multivariate modeling.
SETTING NlmCategory: METHODS
The non-medical use of over-the-counter or prescribed analgesics (NMUA) is a significant public health problem. Little is known about the genetic and environmental etiology of NMUA and how these risks relate to other classes of substance use and misuse. Our aims were to estimate the heritability NMUA and sources of genetic and environmental covariance with cannabis and nicotine use, cannabis and alcohol use disorders and nicotine dependence in Australian twins. Biometrical genetic analyses or twin methods using structural equation univariate and multivariate modeling. Australia.
PARTICIPANTS NlmCategory: METHODS
The non-medical use of over-the-counter or prescribed analgesics (NMUA) is a significant public health problem. Little is known about the genetic and environmental etiology of NMUA and how these risks relate to other classes of substance use and misuse. Our aims were to estimate the heritability NMUA and sources of genetic and environmental covariance with cannabis and nicotine use, cannabis and alcohol use disorders and nicotine dependence in Australian twins. Biometrical genetic analyses or twin methods using structural equation univariate and multivariate modeling. Australia. 2,007 young adult twins (66% female; μ =25.9, SD=3.6, range=18-38) from the Brisbane Longitudinal Twin Study retrospectively assessed between 2009 and 2016.
MEASUREMENTS NlmCategory: METHODS
The non-medical use of over-the-counter or prescribed analgesics (NMUA) is a significant public health problem. Little is known about the genetic and environmental etiology of NMUA and how these risks relate to other classes of substance use and misuse. Our aims were to estimate the heritability NMUA and sources of genetic and environmental covariance with cannabis and nicotine use, cannabis and alcohol use disorders and nicotine dependence in Australian twins. Biometrical genetic analyses or twin methods using structural equation univariate and multivariate modeling. Australia. 2,007 young adult twins (66% female; μ =25.9, SD=3.6, range=18-38) from the Brisbane Longitudinal Twin Study retrospectively assessed between 2009 and 2016. Self-reported NMUA (non-opioid or opioid-based), lifetime nicotine, cannabis and opioid use, DSM-V cannabis and alcohol use disorders and the Fagerström Test for Nicotine Dependence.
FINDINGS NlmCategory: RESULTS
The non-medical use of over-the-counter or prescribed analgesics (NMUA) is a significant public health problem. Little is known about the genetic and environmental etiology of NMUA and how these risks relate to other classes of substance use and misuse. Our aims were to estimate the heritability NMUA and sources of genetic and environmental covariance with cannabis and nicotine use, cannabis and alcohol use disorders and nicotine dependence in Australian twins. Biometrical genetic analyses or twin methods using structural equation univariate and multivariate modeling. Australia. 2,007 young adult twins (66% female; μ =25.9, SD=3.6, range=18-38) from the Brisbane Longitudinal Twin Study retrospectively assessed between 2009 and 2016. Self-reported NMUA (non-opioid or opioid-based), lifetime nicotine, cannabis and opioid use, DSM-V cannabis and alcohol use disorders and the Fagerström Test for Nicotine Dependence. Lifetime NMUA was reported by 19.4% of the sample. Univariate heritability explained 46% (95% CI = 0.29-0.57) of the risks in NMUA. Multivariate analyses revealed that NMUA is moderately associated genetically with cannabis (r =0.41) and nicotine (r =0.45) use, and nicotine dependence (r =0.34). In contrast, the genetic correlations with cannabis (r =0.15) and alcohol (r =0.07) use disorders are weak.
CONCLUSIONS NlmCategory: CONCLUSIONS
The non-medical use of over-the-counter or prescribed analgesics (NMUA) is a significant public health problem. Little is known about the genetic and environmental etiology of NMUA and how these risks relate to other classes of substance use and misuse. Our aims were to estimate the heritability NMUA and sources of genetic and environmental covariance with cannabis and nicotine use, cannabis and alcohol use disorders and nicotine dependence in Australian twins. Biometrical genetic analyses or twin methods using structural equation univariate and multivariate modeling. Australia. 2,007 young adult twins (66% female; μ =25.9, SD=3.6, range=18-38) from the Brisbane Longitudinal Twin Study retrospectively assessed between 2009 and 2016. Self-reported NMUA (non-opioid or opioid-based), lifetime nicotine, cannabis and opioid use, DSM-V cannabis and alcohol use disorders and the Fagerström Test for Nicotine Dependence. Lifetime NMUA was reported by 19.4% of the sample. Univariate heritability explained 46% (95% CI = 0.29-0.57) of the risks in NMUA. Multivariate analyses revealed that NMUA is moderately associated genetically with cannabis (r =0.41) and nicotine (r =0.45) use, and nicotine dependence (r =0.34). In contrast, the genetic correlations with cannabis (r =0.15) and alcohol (r =0.07) use disorders are weak. In young male and female adults in Australia, the non-medical use of over-the-counter or prescribed analgesics (NMUA) appears to have moderate heritability. NMUA is moderately associated with cannabis and nicotine use and nicotine dependence. Its genetic etiology is largely distinct from that of cannabis and alcohol use disorders.
This article is protected by copyright. All rights reserved.
DATE PUBLISHED
2019 Jul 17
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/09/18
revised 2019/06/20
accepted 2019/07/01
entrez 2019/07/18 06:00
pubmed 2019/07/18 06:00
medline 2019/07/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Gillespie NA Gillespie Nathan A NA QIMR Berghofer Medical Research Institute, QLD, Australia.
Bates TC Bates Timothy C TC Department of Psychology, University of Edinburgh, EH8 9JZ, UK.
Hickie IB Hickie Ian B IB Brain and Mind Centre, University of Sydney, NSW, Australia.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute, QLD, Australia.
Verhulst B Verhulst Brad B Psychology Department, Michigan State University, MI, USA.
Kirkpatrick RM Kirkpatrick Robert M RM Virginia Institute for Psychiatric and Behaviour Genetics, Virginia Commonwealth University, VA, USA.
Kendler KS Kendler Kenneth S KS Virginia Institute for Psychiatric and Behaviour Genetics, Virginia Commonwealth University, VA, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, QLD, Australia.
Benotsch EG Benotsch Eric G EG Psychology Department, Virginia Commonwealth University, VA, USA.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Addiction (Abingdon, England)
ISOABBREVIATION: Addiction
YEAR: 2019
MONTH: Jul
DAY: 17
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1360-0443
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Addiction
COUNTRY: England
ISSNLINKING: 0965-2140
NLMUNIQUEID: 9304118
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
comorbidity
gene
non-medical use
over-the-counter
prescribed analgesics
substance use
twin
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's