Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
31301758
TITLE
Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa.
METHODS NlmCategory: METHODS
Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472).
RESULTS NlmCategory: RESULTS
Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472). Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95% confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95% CI = 2.15, 2.86; other EDs: OR = 4.66, 95% CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95% CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95% CI = .31, .42) than with AN (.14, 95% CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes.
CONCLUSIONS NlmCategory: CONCLUSIONS
Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472). Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95% confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95% CI = 2.15, 2.86; other EDs: OR = 4.66, 95% CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95% CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95% CI = .31, .42) than with AN (.14, 95% CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes. We observed stronger genetic association with ADHD for non-AN EDs than for AN, highlighting specific genetic correlation beyond a general genetic factor across psychiatric disorders.
Copyright 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
DATE PUBLISHED
2019 May 15
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2019/01/30
revised 2019/04/15
accepted 2019/04/22
entrez 2019/07/15 06:00
pubmed 2019/07/16 06:00
medline 2019/07/16 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Yao S Yao Shuyang S Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Electronic address: shuyang.yao@ki.se.
Kuja-Halkola R Kuja-Halkola Ralf R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Martin J Martin Joanna J Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Lu Y Lu Yi Y Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Lichtenstein P Lichtenstein Paul P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Norring C Norring Claes C Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Birgegård A Birgegård Andreas A Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
Yilmaz Z Yilmaz Zeynep Z Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Hübel C Hübel Christopher C Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Watson H Watson Hunna H Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Baker J Baker Jessica J Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Almqvist C Almqvist Catarina C Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Eating Disorders Working Group of the Psychiatric Genomics Consortium
Thornton LM Thornton Laura M LM Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Magnusson PK Magnusson Patrik K PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Bulik CM Bulik Cynthia M CM Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Larsson H Larsson Henrik H Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; School of Medical Sciences, Örebro University, Örebro, Sweden.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Adan Roger R
Ando Tetsuya T
Baker Jessica J
Bergen Andrew A
Berrettini Wade W
Birgegård Andreas A
Boni Claudette C
Boraska Perica Vesna V
Brandt Harry H
Burghardt Roland R
Cassina Matteo M
Cesta Carolyn C
Clementi Maurizio M
Coleman Joni J
Cone Roger R
Courtet Philippe P
Crawford Steven S
Crow Scott S
Crowley James J
Danner Unna U
Davis Oliver O
de Zwaan Martina M
Dedoussis George G
Degortes Daniela D
DeSocio Janiece J
Dick Danielle D
Dikeos Dimitris D
Dmitrzak-Weglarz Monika M
Docampo Elisa E
Egberts Karin K
Ehrlich Stefan S
Escaramís Geòrgia G
Esko Tõnu T
Estivill Xavier X
Favaro Angela A
Fernández-Aranda Fernando F
Fichter Manfred M
Finan Chris C
Fischer Krista K
Föcker Manuel M
Foretova Lenka L
Forzan Monica M
Franklin Christopher C
Gaspar Héléna H
Gonidakis Fragiskos F
Gorwood Philip P
Gratacos Monica M
Guillaume Sébastien S
Guo Yiran Y
Hakonarson Hakon H
Halmi Katherine K
Hatzikotoulas Konstantinos K
Hauser Joanna J
Hebebrand Johannes J
Helder Sietske S
Hendriks Judith J
Herpertz-Dahlmann Beate B
Herzog Wolfgang W
Hilliard Christopher C
Hinney Anke A
Huckins Laura L
Hudson James J
Huemer Julia J
Imgart Hartmut H
Inoko Hidetoshi H
Jiménez-Murcia Susana S
Johnson Craig C
Jordan Jenny J
Juréus Anders A
Kalsi Gursharan G
Kaminska Debora D
Kaplan Allan A
Kaprio Jaakko J
Karhunen Leila L
Karwautz Andreas A
Kas Martien M
Kaye Walter W
Kennedy James J
Kennedy Martin M
Keski-Rahkonen Anna A
Kiezebrink Kirsty K
Kim Youl-Ri YR
Klump Kelly K
Knudsen Gun Peggy GP
Koeleman Bobby B
Koubek Doris D
La Via Maria M
Landén Mikael M
Levitan Robert R
Li Dong D
Lichtenstein Paul P
Lilenfeld Lisa L
Lissowska Jolanta J
Magistretti Pierre P
Maj Mario M
Mannik Katrin K
Martin Nicholas N
McDevitt Sara S
McGuffin Peter P
Merl Elisabeth E
Metspalu Andres A
Meulenbelt Ingrid I
Micali Nadia N
Mitchell James J
Mitchell Karen K
Monteleone Palmiero P
Monteleone Alessio Maria AM
Mortensen Preben P
Munn-Chernoff Melissa M
Nacmias Benedetta B
Nilsson Ida I
Norring Claes C
Ntalla Ioanna I
O'Toole Julie J
Pantel Jacques J
Papezova Hana H
Parker Richard R
Rabionet Raquel R
Raevuori Anu A
Rajewski Andrzej A
Ramoz Nicolas N
Rayner N William NW
Reichborn-Kjennerud Ted T
Ricca Valdo V
Ripke Stephan S
Ritschel Franziska F
Roberts Marion M
Rotondo Alessandro A
Rybakowski Filip F
Santonastaso Paolo P
Scherag André A
Schmidt Ulrike U
Schork Nicholas N
Schosser Alexandra A
Seitz Jochen J
Slachtova Lenka L
Slagboom P Eline PE
Slof-Op't Landt Margarita M
Slopien Agnieszka A
Smith Tosha T
Sorbi Sandro S
Strengman Eric E
Strober Michael M
Sullivan Patrick P
Szatkiewicz Jin J
Szeszenia-Dabrowska Neonila N
Tachmazidou Ioanna I
Tenconi Elena E
Thornton Laura L
Tortorella Alfonso A
Tozzi Federica F
Treasure Janet J
Tsitsika Artemis A
Tziouvas Konstantinos K
van Elburg Annemarie A
van Furth Eric E
Wade Tracey T
Wagner Gudrun G
Walton Esther E
Watson Hunna H
Woodside D Blake DB
Yao Shuyang S
Yilmaz Zeynep Z
Zeggini Eleftheria E
Zerwas Stephanie S
Zipfel Stephan S
Alfredsson Lars L
Andreassen Ole O
Aschauer Harald H
Barrett Jeffrey J
Bencko Vladimir V
Carlberg Laura L
Cichon Sven S
Cohen-Woods Sarah S
Dina Christian C
Ding Bo B
Espeseth Thomas T
Floyd James J
Gallinger Steven S
Gambaro Giovanni G
Giegling Ina I
Herms Stefan S
Janout Vladimir V
Julià Antonio A
Klareskog Lars L
Le Hellard Stephanie S
Leboyer Marion M
Lundervold Astri A
Marsal Sara S
Mattingsdal Morten M
Navratilova Marie M
Ophoff Roel R
Palotie Aarno A
Pinto Dalila D
Ripatti Samuli S
Rujescu Dan D
Scherer Stephen S
Scott Laura L
Sladek Robert R
Soranzo Nicole N
Southam Lorraine L
Steen Vidar V
Wichmann H-Erich HE
Widen Elisabeth E
Breen Gerome G
Bulik Cynthia C
JOURNAL
VOLUME:
ISSUE:
TITLE: Biological psychiatry
ISOABBREVIATION: Biol. Psychiatry
YEAR: 2019
MONTH: May
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1873-2402
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Biol Psychiatry
COUNTRY: United States
ISSNLINKING: 0006-3223
NLMUNIQUEID: 0213264
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
ADHD
Anorexia nervosa
Bulimia nervosa
Eating disorders
Genetic epidemiology
Polygenic risk score
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's