Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
31198126
TITLE
Twenty-Five and Up (25Up) Study: A New Wave of the Brisbane Longitudinal Twin Study.
ABSTRACT
The aim of the 25 and Up (25Up) study was to assess a wide range of psychological and behavioral risk factors behind mental illness in a large cohort of Australian twins and their non-twin siblings. Participants had already been studied longitudinally from the age of 12 and most recently in the 19Up study (mean age = 26.1 years, SD = 4.1, range = 20-39). This subsequent wave follows up these twins several years later in life (mean age = 29.7 years, SD = 2.2, range =  22-44). The resulting data set enables additional detailed investigations of genetic pathways underlying psychiatric illnesses in the Brisbane Longitudinal Twin Study (BLTS). Data were collected between 2016 and 2018 from 2540 twins and their non-twin siblings (59% female, including 341 monozygotic complete twin-pairs, 415 dizygotic complete pairs and 1028 non-twin siblings and singletons). Participants were from South-East Queensland, Australia, and the sample was of predominantly European ancestry. The 25Up study collected information on 20 different mental disorders, including depression, anxiety, substance use, psychosis, bipolar and attention-deficit hyper-activity disorder, as well as general demographic information such as occupation, education level, number of children, self-perceived IQ and household environment. In this article, we describe the prevalence, comorbidities and age of onset for all 20 examined disorders. The 25Up study also assessed general and physical health, including physical activity, sleep patterns, eating behaviors, baldness, acne, migraines and allergies, as well as psychosocial items such as suicidality, perceived stress, loneliness, aggression, sleep-wake cycle, sexual identity and preferences, technology and internet use, traumatic life events, gambling and cyberbullying. In addition, 25Up assessed female health traits such as morning sickness, breastfeeding and endometriosis. Furthermore, given that the 25Up study is an extension of previous BLTS studies, 86% of participants have already been genotyped. This rich resource will enable the assessment of epidemiological risk factors, as well as the heritability and genetic correlations of mental conditions.
DATE PUBLISHED
2019 06
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2019/06/15 06:00
medline 2020/01/10 06:00
entrez 2019/06/15 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Mitchell BL Mitchell Brittany L BL Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia.
Campos AI Campos Adrian I AI Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia.
Rentería ME Rentería Miguel E ME Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia.
Parker R Parker Richard R Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia.
Sullivan L Sullivan Lenore L Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia.
McAloney K McAloney Kerrie K Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia.
Couvy-Duchesne B Couvy-Duchesne Baptiste B Institute for Molecular Bioscience,The University of Queensland,Brisbane QLD,Australia.
Medland SE Medland Sarah E SE Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia.
Gillespie NA Gillespie Nathan A NA Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA.
Scott J Scott Jan J Brain and Mind Centre,University of Sydney,Sydney, NSW,Australia.
Zietsch BP Zietsch Brendan P BP School of Psychology,The University of Queensland,Brisbane QLD,Australia.
Lind PA Lind Penelope A PA Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia.
Martin NG Martin Nicholas G NG Department of Genetics & Computational Biology,QIMR Berghofer Medical Research Institute,Brisbane, QLD,Australia.
Hickie IB Hickie Ian B IB Brain and Mind Centre,University of Sydney,Sydney, NSW,Australia.
INVESTIGATORS
JOURNAL
VOLUME: 22
ISSUE: 3
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2019
MONTH: 06
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Mental health
cohort study
genetics
longitudinal
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Anorexia epidemiology
Bipolar Disorder epidemiology
Child epidemiology
Comorbidity epidemiology
Depression epidemiology
Female epidemiology
Humans epidemiology
Longitudinal Studies epidemiology
Male epidemiology
Phenotype epidemiology
Prevalence epidemiology
Queensland epidemiology
Registries statistics & numerical data
Risk Factors statistics & numerical data
Twins, Dizygotic psychology
Twins, Monozygotic psychology
Young Adult psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's