Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
31135366
TITLE
MULTI-SITE META-ANALYSIS OF MORPHOMETRY.
ABSTRACT
Genome-wide association studies (GWAS) link full genome data to a handful of traits. However, in neuroimaging studies, there is an almost unlimited number of traits that can be extracted for full image-wide big data analyses. Large populations are needed to achieve the necessary power to detect statistically significant effects, emphasizing the need to pool data across multiple studies. Neuroimaging consortia, e.g., ENIGMA and CHARGE, are now analyzing MRI data from over 30,000 individuals. Distributed processing protocols extract harmonized features at each site, and pool together only the cohort statistics using meta analysis to avoid data sharing. To date such MRI projects have focused on single measures such as hippocampal volume, yet voxelwise analyses (e.g., tensor-based morphometry; TBM) may help better localize statistical effects. This can lead to 1013 tests for GWAS and become underpowered. We developed an analytical framework for multi-site TBM by performing multi-channel registration to cohort-specific templates. Our results highlight the reliability of the method and the added power over alternative options while preserving single site specificity and opening the doors for well-powered image-wide genome-wide discoveries.
DATE PUBLISHED
2019 May 23
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2019/05/29 06:00
medline 2019/05/29 06:00
entrez 2019/05/29 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Jahanshad N Jahanshad Neda N
Faskowitz JI Faskowitz Joshua I JI
Roshchupkin G Roshchupkin Gennady G
Hibar D Hibar Derrek D
Gutman BA Gutman Boris A BA
Tustison NJ Tustison Nicholas J NJ
Adams HHH Adams Hieab H H HHH
Niessen W Niessen Wiro W
Vernooij MW Vernooij Meike W MW
Ikram MA Ikram M Arfan MA
Zwiers MP Zwiers Marcel P MP
Vasquez AA Vasquez Alejandro Arias AA
Franke B Franke Barbara B
Kroll JL Kroll Jennifer L JL
Mwangi B Mwangi Benson B
Soares JC Soares Jair C JC
Ing A Ing Alex A
Desrivieres S Desrivieres Sylvane S
Schumann G Schumann Gunter G
Hansell NK Hansell Narelle K NK
de Zubicaray GI de Zubicaray Greig I GI
McMahon KL McMahon Katie L KL
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: IEEE/ACM transactions on computational biology and bioinformatics
ISOABBREVIATION: IEEE/ACM Trans Comput Biol Bioinform
YEAR: 2019
MONTH: May
DAY: 23
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1557-9964
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: IEEE/ACM Trans Comput Biol Bioinform
COUNTRY: United States
ISSNLINKING: 1545-5963
NLMUNIQUEID: 101196755
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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