Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30877414
TITLE
Half the Genetic Variance in Vitamin D Concentration is Shared with Skin Colour and Sun Exposure Genes.
ABSTRACT
This study assessed the heritability of 25 hydroxyvitamin D (25(OH)D3) in a large twin cohort and the shared effect of sun exposure and skin colour on 25(OH)D3 variance. Study participants included 1604 twin pairs and their siblings (n = 4020). Twin correlations for 25(OH)D3 concentration were r =0.79 (584 pairs) and r  = 0.52 (1020 pairs) consistent with an average h  = 0.50 throughout the year. Significant phenotypic and genetic seasonal fluctuation was observed in 25(OH)D3 concentrations with heritability decreasing during the winter (h  = 0.37) compared to summer (h  = 0.62). Skin colour (measured both ordinally and quantitatively) and self-reported sun exposure were found to significantly affect 25(OH)D3 concentration. Twins with olive/dark skin had significantly lower 25(OH)D3 concentrations than those with fair/pale skin and multivariate genetic analysis showed that approximately half of the total additive genetic variation in 25(OH)D3 results from genes whose primary influence is on skin colour and sun exposure. Additionally, 37% of the total variance was attributed to shared environmental effects on vitamin D, skin colour and sun exposure measures. These results support a moderate estimate of vitamin D heritability and suggest significant influence of season, skin colour and sun exposure on the genetic variance.
DATE PUBLISHED
2019 Mar 15
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/11/12
accepted 2019/03/01
entrez 2019/03/17 06:00
pubmed 2019/03/17 06:00
medline 2019/03/17 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Mitchell BL Mitchell Brittany L BL Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia. Brittany.mitchell@qimrberghofer.edu.au.
Zhu G Zhu Gu G Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia.
Medland SE Medland Sarah E SE Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia.
Renteria ME Renteria Miguel E ME Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
Eyles DW Eyles Darryl W DW Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia.
Grasby KL Grasby Katrina L KL Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia.
McGrath JJ McGrath John J JJ National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark.
Martin NG Martin Nicholas G NG Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2019
MONTH: Mar
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-3297
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
241944, 552485, 552498, 1031119, 1049894 National Health and Medical Research Council
APP 1007677, APP 1099709 National Health and Medical Research Council
GENERAL NOTE
KEYWORDS
KEYWORD
Genetics
Heritability
Skin colour
Sun exposure
Twin
Vitamin D
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's