Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
30703394
TITLE
Associations between brain structure and perceived intensity of sweet and bitter tastes.
ABSTRACT
Functional neuroimaging studies have identified brain regions associated with human taste perception, but only a few have investigated the associations with brain structure. Here, in this exploratory study, we examined the association between the volumes of 82 regions of interest (ROI) and the perceived intensities of sweet (a weighted mean rating of glucose, fructose, aspartame, neohesperidin dihydrochalcone) and bitter (propylthiouracil, quinine, caffeine) substances in a large Australian healthy cohort from the Queensland Twin IMaging (QTIM, n = 559) study and the perceived intensity of quinine in a large U.S. healthy cohort from the Human Connectome Project (HCP, n = 1101). In QTIM, the volumes of 3 cortical (right cuneus gyrus, left transverse temporal gyrus, right inferior temporal gyrus) and one subcortical structure (both left and right caudate) were associated with more than one taste stimulus (P < 0.05) and tended to be associated with both sweet and bitter tastes in the same direction, suggesting these ROIs were more broadly tuned for taste sensation. A further 11 ROIs were associated with a specific taste (sweetness: 4; propylthiouracil: 3; caffeine: 2; quinine: 2). In HCP, volumes of 5 ROIs were associated with quinine bitterness. The quinine-left entorhinal cortex association was found in both QTIM (r = -0.12, P = 3.7 × 10 ) and HCP (r = -0.06, P = 2.0 × 10 ). This study provides the first evidence that, even in healthy people, variation in brain structure is associated with taste intensity ratings, and provides new insights into the brain gustatory circuit.
Copyright 2019. Published by Elsevier B.V.
DATE PUBLISHED
2019 Jan 28
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/11/12
revised 2019/01/12
accepted 2019/01/25
entrez 2019/02/01 06:00
pubmed 2019/02/01 06:00
medline 2019/02/01 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hwang LD Hwang Liang-Dar LD Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia; University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Electronic address: d.hwang@uq.edu.au.
Strike LT Strike Lachlan T LT Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Couvy-Duchesne B Couvy-Duchesne Baptiste B Institute for Bioscience, University of Queensland, Brisbane, Queensland, Australia.
de Zubicaray GI de Zubicaray Greig I GI Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
McMahon K McMahon Katie K Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia; School of Clinical Science, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
Breslin PAS Breslin Paul A S PAS Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA; Dept. of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, USA.
Reed DR Reed Danielle R DR Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Wright MJ Wright Margaret J MJ Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia; Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Behavioural brain research
ISOABBREVIATION: Behav. Brain Res.
YEAR: 2019
MONTH: Jan
DAY: 28
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1872-7549
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Behav Brain Res
COUNTRY: Netherlands
ISSNLINKING: 0166-4328
NLMUNIQUEID: 8004872
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
bitter
brain structure
gustatory cortex
sweet
taste
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's