Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
30661510
TITLE
Social Competence in Parents Increases Children's Educational Attainment: Replicable Genetically-Mediated Effects of Parenting Revealed by Non-Transmitted DNA.
ABSTRACT
We recently reported an association of offspring educational attainment with polygenic risk scores (PRS) computed on parent's non-transmitted alleles for educational attainment using the second GWAS meta-analysis article on educational attainment published by the Social Science Genetic Association Consortium. Here we test the replication of these findings using a more powerful PRS from the third GWAS meta-analysis article by the Consortium. Each of the key findings of our previous paper is replicated using this improved PRS (N = 2335 adolescent twins and their genotyped parents). The association of children's attainment with their own PRS increased substantially with the standardized effect size, moving from β = 0.134, 95% CI = 0.079, 0.188 for EA2, to β = 0.223, 95% CI = 0.169, 0.278, p < .001, for EA3. Parent's PRS again predicted the socioeconomic status (SES) they provided to their offspring and increased from β = 0.201, 95% CI = 0.147, 0.256 to β = 0.286, 95% CI = 0.239, 0.333. Importantly, the PRS for alleles not transmitted to their offspring - therefore acting via the parenting environment - was increased in effect size from β = 0.058, 95% CI = 0.003, 0.114 to β = 0.067, 95% CI = 0.012, 0.122, p = .016. As previously found, this non-transmitted genetic effect was fully accounted for by parental SES. The findings reinforce the conclusion that genetic effects of parenting are substantial, explain approximately one-third the magnitude of an individual's own genetic inheritance and are mediated by parental socioeconomic competence.
DATE PUBLISHED
2019 Jan 21
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2019/01/22 06:00
pubmed 2019/01/22 06:00
medline 2019/01/22 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Bates TC Bates Timothy C TC Department of Psychology,University of Edinburgh,Edinburgh,UK.
Maher BS Maher Brion S BS Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
Colodro-Conde L Colodro-Conde Lucía L QIMR Berghofer Medical Research Institute,Brisbane, Queensland,Australia.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute,Brisbane, Queensland,Australia.
McAloney K McAloney Kerrie K QIMR Berghofer Medical Research Institute,Brisbane, Queensland,Australia.
Wright MJ Wright Margaret J MJ Queensland Brain Institute,University of Queensland,Brisbane, Queensland,Australia.
Hansell NK Hansell Narelle K NK Queensland Brain Institute,University of Queensland,Brisbane, Queensland,Australia.
Okbay A Okbay Aysu A Department of Economics, School of Business and Economics,Vrije Universiteit Amsterdam,Amsterdam,The Netherlands.
Kendler KS Kendler Kenneth S KS Virginia Institute of Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute,Brisbane, Queensland,Australia.
Gillespie NA Gillespie Nathan A NA Virginia Institute of Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2019
MONTH: Jan
DAY: 21
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
PRS
SES
educational attainment
non-transmitted genotype
parental environment
parenting
polygenic risk scores
socioeconomic status
virtual-parent design
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's