Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30514905
TITLE
Identification of 55,000 Replicated DNA Methylation QTL.
ABSTRACT
DNA methylation plays an important role in the regulation of transcription. Genetic control of DNA methylation is a potential candidate for explaining the many identified SNP associations with disease that are not found in coding regions. We replicated 52,916 cis and 2,025 trans DNA methylation quantitative trait loci (mQTL) using methylation from whole blood measured on Illumina HumanMethylation450 arrays in the Brisbane Systems Genetics Study (n = 614 from 177 families) and the Lothian Birth Cohorts of 1921 and 1936 (combined n = 1366). The trans mQTL SNPs were found to be over-represented in 1 Mbp subtelomeric regions, and on chromosomes 16 and 19. There was a significant increase in trans mQTL DNA methylation sites in upstream and 5' UTR regions. The genetic heritability of a number of complex traits and diseases was partitioned into components due to mQTL and the remainder of the genome. Significant enrichment was observed for height (p = 2.1 × 10 ), ulcerative colitis (p = 2 × 10 ), Crohn's disease (p = 6 × 10 ) and coronary artery disease (p = 5.5 × 10 ) when compared to a random sample of SNPs with matched minor allele frequency, although this enrichment is explained by the genomic location of the mQTL SNPs.
DATE PUBLISHED
2018 Dec 04
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2016/04/14
accepted 2018/11/12
entrez 2018/12/06 06:00
pubmed 2018/12/06 06:00
medline 2018/12/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
McRae AF McRae Allan F AF Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia. a.mcrae@uq.edu.au.
Marioni RE Marioni Riccardo E RE Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Shah S Shah Sonia S The Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia.
Yang J Yang Jian J Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.
Powell JE Powell Joseph E JE The Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia.
Harris SE Harris Sarah E SE Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Gibson J Gibson Jude J Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
Henders AK Henders Anjali K AK The Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia.
Bowdler L Bowdler Lisa L QIMR Berghofer Medical Research Institute, Brisbane, 4029, QLD, Australia.
Painter JN Painter Jodie N JN QIMR Berghofer Medical Research Institute, Brisbane, 4029, QLD, Australia.
Murphy L Murphy Lee L Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, 4029, QLD, Australia.
Starr JM Starr John M JM Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Wray NR Wray Naomi R NR Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.
Deary IJ Deary Ian J IJ Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Visscher PM Visscher Peter M PM Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Montgomery GW Montgomery Grant W GW The Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 8
ISSUE: 1
TITLE: Scientific reports
ISOABBREVIATION: Sci Rep
YEAR: 2018
MONTH: Dec
DAY: 04
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2045-2322
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Sci Rep
COUNTRY: England
ISSNLINKING: 2045-2322
NLMUNIQUEID: 101563288
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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