Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30442986
TITLE
Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization.
ABSTRACT
Consumption of coffee, tea and alcohol might be shaped by individual differences in bitter taste perception but inconsistent observational findings provide little insight regarding causality. We conducted Mendelian randomization analyses using genetic variants associated with the perception of bitter substances (rs1726866 for propylthiouracil [PROP], rs10772420 for quinine and rs2597979 for caffeine) to evaluate the intake of coffee, tea and alcohol among up to 438,870 UK Biobank participants. A standard deviation (SD) higher in genetically predicted bitterness of caffeine was associated with increased coffee intake (0.146 [95%CI: 0.103, 0.189] cups/day), whereas a SD higher in those of PROP and quinine was associated with decreased coffee intake (-0.021 [-0.031, -0.011] and -0.081 [-0.108, -0.054] cups/day respectively). Higher caffeine perception was also associated with increased risk of being a heavy (>4 cups/day) coffee drinker (OR 1.207 [1.126, 1.294]). Opposite pattern of associations was observed for tea possibly due to the inverse relationship between both beverages. Alcohol intake was only negatively associated with PROP perception (-0.141 [-1.88, -0.94] times/month per SD increase in PROP bitterness). Our results reveal that bitter perception is causally associated with intake of coffee, tea and alcohol, suggesting a role of bitter taste in the development of bitter beverage consumption.
DATE PUBLISHED
2018 Nov 15
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/05/14
accepted 2018/10/19
entrez 2018/11/17 06:00
pubmed 2018/11/18 06:00
medline 2018/11/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ong JS Ong Jue-Sheng JS School of Medicine, University of Queensland, Brisbane, Australia. juesheng.ong@qimrberghofer.edu.au.
Hwang DL Hwang Daniel Liang-Dar DL University of Queensland Diamantina Institute, University of Queensland, Brisbane, Australia. d.hwang@uq.edu.au.
Zhong VW Zhong Victor W VW Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
An J An Jiyuan J QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Gharahkhani P Gharahkhani Puya P QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Breslin PAS Breslin Paul A S PAS Department of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, 08901, USA.
Wright MJ Wright Margaret J MJ Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, 4072, Australia.
Lawlor DA Lawlor Deborah A DA Population Health Science, Bristol Medical School, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PS, UK.
Whitfield J Whitfield John J QIMR Berghofer Medical Research Institute, Brisbane, Australia.
MacGregor S MacGregor Stuart S QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Cornelis MC Cornelis Marilyn C MC Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
INVESTIGATORS
JOURNAL
VOLUME: 8
ISSUE: 1
TITLE: Scientific reports
ISOABBREVIATION: Sci Rep
YEAR: 2018
MONTH: Nov
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2045-2322
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Sci Rep
COUNTRY: England
ISSNLINKING: 2045-2322
NLMUNIQUEID: 101563288
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
GNT1125200 Department of Health | National Health and Medical Research Council (NHMRC)
APP1123248 Department of Health | National Health and Medical Research Council (NHMRC)
241944 Department of Health | National Health and Medical Research Council (NHMRC)
1031119 Department of Health | National Health and Medical Research Council (NHMRC)
14SFRN20480260 American Heart Association (American Heart Association, Inc.)
DC02995 U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)
R03DC01337301A1 U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)
DP0664638 Australian Research Council (ARC)
DP1093900 Australian Research Council (ARC)
MC_UU_12013/5 Medical Research Council (MRC)
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