Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30287268
TITLE
The anorexia nervosa genetics initiative (ANGI): Overview and methods.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN as well as ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research.
METHODS NlmCategory: METHODS
ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H.
RESULTS NlmCategory: RESULTS
Blood samples and clinical information were collected from 13,364 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable.
CONCLUSIONS NlmCategory: CONCLUSIONS
Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.
Copyright 2018. Published by Elsevier Inc.
DATE PUBLISHED
2018 Oct 01
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2018/05/15
revised 2018/09/17
accepted 2018/09/28
entrez 2018/10/06 06:00
pubmed 2018/10/06 06:00
medline 2018/10/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Thornton LM Thornton Laura M LM University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Munn-Chernoff MA Munn-Chernoff Melissa A MA University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Baker JH Baker Jessica H JH University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Juréus A Juréus Anders A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm SE-171 77, Sweden.
Parker R Parker Richard R Royal Brisbane Hospital QLD, QIMR Berghofer Medical Research Institute, Locked Bag 2000, 4029, Australia.
Henders AK Henders Anjali K AK The University of Queensland, Brisbane, QLD 4072, Australia.
Larsen JT Larsen Janne T JT Aarhus University, Norde Ringgade 1, Aarhus 8000, Denmark.
Petersen L Petersen Liselotte L Aarhus University, Norde Ringgade 1, Aarhus 8000, Denmark.
Watson HJ Watson Hunna J HJ University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia; Curtin University, GPO Box U1987, Perth, WA 6845, Australia.
Yilmaz Z Yilmaz Zeynep Z University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kirk KM Kirk Katherine M KM Royal Brisbane Hospital QLD, QIMR Berghofer Medical Research Institute, Locked Bag 2000, 4029, Australia.
Gordon S Gordon Scott S Royal Brisbane Hospital QLD, QIMR Berghofer Medical Research Institute, Locked Bag 2000, 4029, Australia.
Leppä VM Leppä Virpi M VM Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm SE-171 77, Sweden.
Martin FC Martin Felicity C FC Royal Brisbane Hospital QLD, QIMR Berghofer Medical Research Institute, Locked Bag 2000, 4029, Australia.
Whiteman DC Whiteman David C DC Royal Brisbane Hospital QLD, QIMR Berghofer Medical Research Institute, Locked Bag 2000, 4029, Australia.
Olsen CM Olsen Catherine M CM Royal Brisbane Hospital QLD, QIMR Berghofer Medical Research Institute, Locked Bag 2000, 4029, Australia.
Werge TM Werge Thomas M TM iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Bartholin Alle 6, Aarhus 8000, Denmark; Mental Health Services, Institute for Biological Psychiatry, MHC Sct. Hans, Kristineberg 3, Copenhagen 2100, Denmark; University of Copenhagen, Nørregade 10, Copenhagen DK-1165, Denmark.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm SE-171 77, Sweden.
Kaye W Kaye Walter W University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Bergen AW Bergen Andrew W AW Biorealm Research, 6101 W Centinela Ave # 270, Culver, CA 90230, USA; Oregon Research Institute, Eugene, OR 97403, USA.
Halmi KA Halmi Katherine A KA Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
Strober M Strober Michael M University of California at Los Angeles, Los Angeles, CA 90095, USA.
Kaplan AS Kaplan Allan S AS University of Toronto, 27 King's College Circle, Toronto, ON M5S 1A1, Canada.
Blake Woodside D Blake Woodside D D University of Toronto, 27 King's College Circle, Toronto, ON M5S 1A1, Canada; Toronto General Hospital, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada.
Mitchell J Mitchell James J Neuropsychiatric Research Institute, 120 8th Street South, Fargo, ND 58103, USA.
Johnson CL Johnson Craig L CL Eating Recovery Center, 7351 E. Lowry Blvd., Suite 200, Denver, CO 80230, USA.
Brandt H Brandt Harry H The Center for Eating Disorders at Sheppard Pratt, 6501 N. Charles Street, Baltimore, MD 21204, USA.
Crawford S Crawford Steven S The Center for Eating Disorders at Sheppard Pratt, 6501 N. Charles Street, Baltimore, MD 21204, USA.
John Horwood L John Horwood L L Christchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand.
Boden JM Boden Joseph M JM Christchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand.
Pearson JF Pearson John F JF Christchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand.
Duncan LE Duncan Laramie E LE Stanford University, 450 Serra Mall, Stanford, CA 94305-2004, USA.
Grove J Grove Jakob J Aarhus University, Norde Ringgade 1, Aarhus 8000, Denmark.
Mattheisen M Mattheisen Manuel M Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm SE-171 77, Sweden; Aarhus University, Norde Ringgade 1, Aarhus 8000, Denmark; Stockholm Health Care Services, County Council, Box 45436, Stockholm 104 31, Sweden; University of Würzburg, Sanderring 2, Würzburg 97070, Germany.
Jordan J Jordan Jennifer J Christchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand.
Kennedy MA Kennedy Martin A MA Christchurch School of Medicine & Health Sciences, University of Otago, 2 Riccarton Avenue, PO Box 4345, Christchurch 8140, New Zealand.
Birgegård A Birgegård Andreas A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm SE-171 77, Sweden; Stockholm Health Care Services, County Council, Box 45436, Stockholm 104 31, Sweden.
Lichtenstein P Lichtenstein Paul P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm SE-171 77, Sweden.
Norring C Norring Claes C Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm SE-171 77, Sweden; Stockholm Health Care Services, County Council, Box 45436, Stockholm 104 31, Sweden.
Wade TD Wade Tracey D TD Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia.
Montgomery GW Montgomery Grant W GW The University of Queensland, Brisbane, QLD 4072, Australia.
Martin NG Martin Nicholas G NG Royal Brisbane Hospital QLD, QIMR Berghofer Medical Research Institute, Locked Bag 2000, 4029, Australia.
Landén M Landén Mikael M Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm SE-171 77, Sweden; Gothenburg University, Box 100, Gothenburg SE-405 30, Sweden.
Mortensen PB Mortensen Preben Bo PB Aarhus University, Norde Ringgade 1, Aarhus 8000, Denmark; University of Copenhagen, Nørregade 10, Copenhagen DK-1165, Denmark.
Sullivan PF Sullivan Patrick F PF University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm SE-171 77, Sweden.
Bulik CM Bulik Cynthia M CM University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm SE-171 77, Sweden. Electronic address: cbulik@med.unc.edu.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Contemporary clinical trials
ISOABBREVIATION: Contemp Clin Trials
YEAR: 2018
MONTH: Oct
DAY: 01
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1559-2030
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Contemp Clin Trials
COUNTRY: United States
ISSNLINKING: 1551-7144
NLMUNIQUEID: 101242342
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Anorexia nervosa
Eating disorders
Genome-wide association
Psychiatric genetics
Psychiatric genomics consortium
Social media
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's