Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30260901
TITLE
Candidate genes for novelty-seeking: a meta-analysis of association studies of DRD4 exon III and COMT Val158Met.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
Two widely studied genetic polymorphisms in the dopaminergic system [DRD4 exon III variable number of tandem repeat (VNTR) and COMT Val158Met] have been reported to be associated with novelty-seeking, but the results have been highly inconsistent. Therefore, a meta-analysis of the associations between these two polymorphisms and novelty-seeking was conducted.
PARTICIPANTS AND METHODS NlmCategory: METHODS
For DRD4, 24 studies comprising 27 samples and including 4933 participants were selected. Genotype grouping, sex, mean age, ethnicity, and sample characteristics were examined as moderators. For COMT, nine studies comprising 13 samples and including 2633 participants were selected. Sex, mean age, ethnicity, and sample characteristics were included as moderators. We also tested for possible publication bias.
RESULTS NlmCategory: RESULTS
The significant association between the DRD4 polymorphism and novelty-seeking was supported, but no association was found between the COMT polymorphism and novelty-seeking. In addition, our findings revealed that sex and age both directly moderate the relationship between DRD4 and novelty-seeking. Meanwhile, ethnicity can interact with age, sex, and genotype grouping, and age and sex can interact with each other, to moderate the association between the DRD4 exon III VNTR polymorphism and novelty-seeking.
CONCLUSION NlmCategory: CONCLUSIONS
Our results provide evidence of association between the DRD4 exon III VNTR polymorphism and novelty-seeking, which is inconsistent with the results of previous meta-analysis. Furthermore, several direct and indirect moderators are also identified to explain contradictory results in the existing literature. However, our results regarding COMT are consistent with those of previous meta-analysis.
DATE PUBLISHED
2018 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2018/09/28 06:00
medline 2018/09/28 06:00
entrez 2018/09/28 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
He Y He Yiqing Y Education Science Research Center, Tianjin University, Tianjin.
Martin N Martin Nick N Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Zhu G Zhu Gu G Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Liu Y Liu Yangyang Y Department of Psychology, Nanjing University, Nanjing, China.
INVESTIGATORS
JOURNAL
VOLUME: 28
ISSUE: 6
TITLE: Psychiatric genetics
ISOABBREVIATION: Psychiatr. Genet.
YEAR: 2018
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1473-5873
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Psychiatr Genet
COUNTRY: England
ISSNLINKING: 0955-8829
NLMUNIQUEID: 9106748
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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