Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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30160223
TITLE
Genetic and environmental influences on gambling disorder liability: a replication and combined analysis of two twin studies.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Gambling disorder (GD), recognized in Diagnostic and Statistical Manual of Mental Disorders, Version 5 (DSM-5) as a behavioral addiction, is associated with a range of adverse outcomes. However, there has been little research on the genetic and environmental influences on the development of this disorder. This study reports results from the largest twin study of GD conducted to date.
METHODS NlmCategory: METHODS
Replication and combined analyses were based on samples of 3292 (mean age 31.8, born 1972-79) and 4764 (mean age 37.7, born 1964-71) male, female, and unlike-sex twin pairs from the Australian Twin Registry. Univariate biometric twin models estimated the proportion of variation in the latent GD liability that could be attributed to genetic, shared environmental, and unique environmental factors, and whether these differed quantitatively or qualitatively for men and women.
RESULTS NlmCategory: RESULTS
In the replication study, when using a lower GD threshold, there was evidence for significant genetic (60%; 95% confidence interval (CI) 45-76%) and unique environmental (40%; 95% CI 24-56%), but not shared environmental contributions (0%; 95% CI 0-0%) to GD liability; this did not significantly differ from the original study. In the combined analysis, higher GD thresholds (such as one consistent with DSM-5 GD) and a multiple threshold definitions of GD yielded similar results. There was no evidence for quantitative or qualitative sex differences in the liability for GD.
CONCLUSIONS NlmCategory: CONCLUSIONS
Twin studies of GD are few in number but they tell a remarkably similar story: substantial genetic and unique environmental influences, with no evidence for shared environmental contributions or sex differences in GD liability.
DATE PUBLISHED
2018 Aug 30
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2018/08/31 06:00
pubmed 2018/08/31 06:00
medline 2018/08/31 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Davis CN Davis Christal N CN University of Missouri,Columbia, MO,USA.
Slutske WS Slutske Wendy S WS University of Missouri,Columbia, MO,USA.
Martin NG Martin Nicholas G NG QIMR Berghofer,Brisbane, Queensland,Australia.
Agrawal A Agrawal Arpana A Washington University School of Medicine,St. Louis, MO,USA.
Lynskey MT Lynskey Michael T MT King's College London Institute of Psychiatry, Psychology & Neuroscience,London,UK.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 2018
MONTH: Aug
DAY: 30
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1469-8978
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01 DA018267 NIDA NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
T32 AA013526 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Behavioral genetics
gambling disorder
sex differences
twins
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's