Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
30017014
TITLE
The Genetic Relationship Between Psychological Distress, Somatic Distress, Affective Disorders, and Substance Use in Young Australian Adults: A Multivariate Twin Study.
ABSTRACT
Psychological distress (PSYCH), somatic distress (SOMA), affective disorders (AD), and substance use (SU) frequently co-occur. The genetic relationship between PSYCH and SOMA, however, remains understudied. We examined the genetic and environmental influences on these two disorders and their comorbid AD and SU using structural equation modeling. Self-reported PSYCH and SOMA were measured in 1,548 twins using the two subscales of a 12-item questionnaire, the Somatic and Psychological Health Report. Its reliability and psychometric properties were examined. Six ADs, involvement of licit and illicit substance, and two SU disorders were obtained from 1,663-2,132 twins using the World Mental Health Composite International Diagnostic Interview and/or from an online adaption of the same. SU phenotypes (heritability: 49-79%) were found to be more heritable than the affective disorder phenotypes (heritability: 32-42%), SOMA (heritability: 25%), and PSYCH (heritability: 23%). We fit separate non-parametric item response theory models for PSYCH, SOMA, AD, and SU. The IRT scores were used as the refined phenotypes for fitting multivariate genetic models. The best-fitting model showed the similar amount of genetic overlap between PSYCH-AD (genetic correlation rG = 0.49) and SOMA-AD (rG =0.53), as well as between PSYCH-SU (rG = 0.23) and SOMA-SU (rG = 0.25). Unique environmental factors explained 53% to 76% of the variance in each of these four phenotypes, whereas additive genetic factors explained 17% to 46% of the variance. The covariance between the four phenotypes was largely explained by unique environmental factors. Common genetic factor had a significant influence on all the four phenotypes, but they explained a moderate portion of the covariance.
DATE PUBLISHED
2018 Jul 18
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2018/07/19 06:00
pubmed 2018/07/19 06:00
medline 2018/07/19 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Chang LH Chang Lun-Hsien LH Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Couvy-Duchesne B Couvy-Duchesne Baptiste B Institute for Molecular Bioscience,University of Queensland,Brisbane,Queensland,Australia.
Medland SE Medland Sarah E SE Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Gillespie NA Gillespie Nathan A NA Virginia Institute for Psychiatric and Behavioural Genetics,Virginia Commonwealth University,Richmond,VA,USA.
Hickie IB Hickie Ian B IB Brain and Mind Centre,University of Sydney,Sydney,New South Wales,Australia.
Parker R Parker Richard R Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2018
MONTH: Jul
DAY: 18
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
addiction
genetics
item response theory
psychiatric disorders
psychometrics
social anxiety
structural equation modeling
twin studies
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's