Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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29844566
TITLE
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
ABSTRACT
) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
DATE PUBLISHED
2018 May 29
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/08/31
accepted 2018/04/23
entrez 2018/05/31 06:00
pubmed 2018/05/31 06:00
medline 2018/05/31 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Davies G Davies Gail G Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Lam M Lam Max M Institute of Mental Health, Singapore, 539747, Singapore.
Harris SE Harris Sarah E SE Medical Genetics Section, Centre for Genomic & Experimental Medicine, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Trampush JW Trampush Joey W JW Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, 90033, CA, USA.
Luciano M Luciano Michelle M Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Hill WD Hill W David WD Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Hagenaars SP Hagenaars Saskia P SP Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK.
Ritchie SJ Ritchie Stuart J SJ Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Marioni RE Marioni Riccardo E RE Medical Genetics Section, Centre for Genomic & Experimental Medicine, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Fawns-Ritchie C Fawns-Ritchie Chloe C Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Liewald DCM Liewald David C M DCM Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Okely JA Okely Judith A JA Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Ahola-Olli AV Ahola-Olli Ari V AV Department of Internal Medicine, Satakunta Central Hospital, Pori, 28100, Finland.
Barnes CLK Barnes Catriona L K CLK Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Bertram L Bertram Lars L Max Planck Institute for Molecular Genetics, Berlin, 14195, Germany.
Bis JC Bis Joshua C JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, Washington, USA.
Burdick KE Burdick Katherine E KE Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, MA, USA.
Christoforou A Christoforou Andrea A Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, 5020, Norway.
DeRosse P DeRosse Pamela P Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, 11030, NY, USA.
Djurovic S Djurovic Srdjan S Department of Medical Genetics, Oslo University Hospital, University of Bergen, Oslo, 0424, Norway.
Espeseth T Espeseth Thomas T Division of Mental Health and Addiction, Oslo University Hospital, Oslo, 0315, Norway.
Giakoumaki S Giakoumaki Stella S Department of Psychology, University of Crete, Crete, GR-74100, Greece.
Giddaluru S Giddaluru Sudheer S Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, 5020, Norway.
Gustavson DE Gustavson Daniel E DE Center for Behavior Genetics of Aging, University of California, San Diego, 92093, CA, USA.
Hayward C Hayward Caroline C Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Hofer E Hofer Edith E Institute of Medical Informatics Statistics and Documentation, Medical University of Graz, Graz, 8036, Austria.
Ikram MA Ikram M Arfan MA Department of Neurology, Erasmus University Medical Center, Rotterdam, xxxxxx, The Netherlands.
Karlsson R Karlsson Robert R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Knowles E Knowles Emma E Department of Psychiatry, Yale University School of Medicine, New Haven, 06511, CT, USA.
Lahti J Lahti Jari J Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, 00014, Finland.
Leber M Leber Markus M Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, D-50937, Germany.
Li S Li Shuo S Department of Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.
Mather KA Mather Karen A KA Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 2031, Australia.
Melle I Melle Ingrid I Department of Psychology, University of Oslo, Oslo, 0373, Norway.
Morris D Morris Derek D Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, H91 TK33, Ireland.
Oldmeadow C Oldmeadow Christopher C Medical Research Institute and Faculty of Health, University of Newcastle, New South Wa0les, 2308, Australia.
Palviainen T Palviainen Teemu T Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.
Payton A Payton Antony A Centre for EpidemiologyDivision of Population Health, Health Services Research & Primary Care, The University of Manchester, Manchester, M13 9PL, UK.
Pazoki R Pazoki Raha R Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.
Petrovic K Petrovic Katja K Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, 8036, Austria.
Reynolds CA Reynolds Chandra A CA Department of Psychology, University of California Riverside, Riverside, 92521, CA, USA.
Sargurupremraj M Sargurupremraj Muralidharan M University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000, Bordeaux, France.
Scholz M Scholz Markus M LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.
Smith JA Smith Jennifer A JA Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
Smith AV Smith Albert V AV University of Iceland, Reykjavik, 101, Iceland.
Terzikhan N Terzikhan Natalie N Department of Respiratory Medicine, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
Thalamuthu A Thalamuthu Anbupalam A Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 2031, Australia.
Trompet S Trompet Stella S Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, 2333, The Netherlands.
van der Lee SJ van der Lee Sven J SJ Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.
Ware EB Ware Erin B EB Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
Windham BG Windham B Gwen BG Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, 39216, MS, USA.
Wright MJ Wright Margaret J MJ Centre for Advanced Imaging, University of Queensland, Brisbane, 4072, Australia.
Yang J Yang Jingyun J Department of Neurological Sciences, Rush University Medical Center, Chicago, 60612, IL, USA.
Yu J Yu Jin J Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, 11030, NY, USA.
Ames D Ames David D Academic Unit for Psychiatry of Old Age, University of Melbourne, St George's Hospital, Kew, 3010, Australia.
Amin N Amin Najaf N Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.
Amouyel P Amouyel Philippe P Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-LabEx DISTALZ, F-59000, Lille, France.
Andreassen OA Andreassen Ole A OA Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, 0372, Norway.
Armstrong NJ Armstrong Nicola J NJ Mathematics and Statistics, Murdoch University, Perth, 6150, Australia.
Assareh AA Assareh Amelia A AA Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 2031, Australia.
Attia JR Attia John R JR Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New South Wales, 2305, Australia.
Attix D Attix Deborah D Psychiatry and Behavioral Sciences, Division of Medical Psychology, and Department of Neurology, Duke University Medical Center, Durham, 27708, NC, USA.
Avramopoulos D Avramopoulos Dimitrios D McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, 21287, USA.
Bennett DA Bennett David A DA Department of Neurological Sciences, Rush University Medical Center, Chicago, 60612, IL, USA.
Böhmer AC Böhmer Anne C AC Department of Genomics, Life and Brain Center, University of Bonn, Bonn, 53113, Germany.
Boyle PA Boyle Patricia A PA Departments of Behavioral Sciences, Rush University Medical Center, Chicago, 60612, IL, USA.
Brodaty H Brodaty Henry H Dementia Centre for Research Collaboration, University of New South Wales, Sydney, 2031, NSW, Australia.
Campbell H Campbell Harry H Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Cannon TD Cannon Tyrone D TD Department of Psychology, Yale University, New Haven, 06520, CT, USA.
Cirulli ET Cirulli Elizabeth T ET Human Longevity Inc, Durham, 27709, NC, USA.
Congdon E Congdon Eliza E UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, 90024, CA, USA.
Conley ED Conley Emily Drabant ED 23andMe, Inc., Mountain View, 94041, CA, USA.
Corley J Corley Janie J Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Cox SR Cox Simon R SR Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Dale AM Dale Anders M AM Department of Radiology, University of California, San Diego, La Jolla, 92093, CA, USA.
Dehghan A Dehghan Abbas A MRC-PHE Centre for Environment, School of Public Health, Imperial College London, London, W2 1PG, UK.
Dick D Dick Danielle D Department of Psychology, Virginia Commonwealth University, Richmond, 23284, VA, USA.
Dickinson D Dickinson Dwight D Clinical and Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, 20892, MD, USA.
Eriksson JG Eriksson Johan G JG Folkhälsan Research Centre, Helsinki, 2018, Finland.
Evangelou E Evangelou Evangelos E National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
Ford I Ford Ian I Robertson Centre for Biostatistics, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
Freimer NA Freimer Nelson A NA UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, 90024, CA, USA.
Gao H Gao He H Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.
Giegling I Giegling Ina I Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, 06108, Germany.
Gillespie NA Gillespie Nathan A NA Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298, VA, USA.
Gordon SD Gordon Scott D SD QIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.
Gottesman RF Gottesman Rebecca F RF Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, 21205, MD, USA.
Griswold ME Griswold Michael E ME Department of Data Science, University of Mississippi Medical Center, Jackson, 39216, MS, USA.
Gudnason V Gudnason Vilmundur V University of Iceland, Reykjavik, 101, Iceland.
Harris TB Harris Tamara B TB Intramural Research Program National Institutes on Aging, National Institutes of Health, Bethesda, 20892, MD, USA.
Hartmann AM Hartmann Annette M AM Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, 06108, Germany.
Hatzimanolis A Hatzimanolis Alex A Neurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, 11521, Greece.
Heiss G Heiss Gerardo G Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, 27599, NC, USA.
Holliday EG Holliday Elizabeth G EG Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New South Wales, 2305, Australia.
Joshi PK Joshi Peter K PK Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Kähönen M Kähönen Mika M Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
Kardia SLR Kardia Sharon L R SLR Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Karlsson I Karlsson Ida I Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Kleineidam L Kleineidam Luca L Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, 53127, Germany.
Knopman DS Knopman David S DS Department of Neurology, Mayo Clinic, Rochester, 55905, MN, USA.
Kochan NA Kochan Nicole A NA Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, 2031, Australia.
Konte B Konte Bettina B Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, 06108, Germany.
Kwok JB Kwok John B JB School of Medical Sciences, University of New South Wales, Sydney, 2052, Australia.
Le Hellard S Le Hellard Stephanie S Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, 5020, Norway.
Lee T Lee Teresa T Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, 2031, Australia.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
Li SC Li Shu-Chen SC Technische Universität Dresden, Dresden, 01187, Germany.
Liu T Liu Tian T Max Planck Institute for Human Development, Berlin, 14195, Germany.
Koini M Koini Marisa M Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, 8036, Austria.
London E London Edythe E UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, 90024, CA, USA.
Longstreth WT Jr Longstreth Will T WT Department of Epidemiology, University of Washington, Seattle, 98195, WA, USA.
Lopez OL Lopez Oscar L OL Department of Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, 15213, PA, USA.
Loukola A Loukola Anu A Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.
Luck T Luck Tobias T Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, 04103, Germany.
Lundervold AJ Lundervold Astri J AJ K. G. Jebsen Center for Neuropsychiatry, University of Bergen, Bergen, N-5009, Norway.
Lundquist A Lundquist Anders A Department of Statistics, USBE Umeå University, S-907 97, Umeå, Sweden.
Lyytikäinen LP Lyytikäinen Leo-Pekka LP Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072, Australia.
Murray AD Murray Alison D AD The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
Need AC Need Anna C AC Division of Brain Sciences, Department of Medicine, Imperial College, London, SW7 2AZ, UK.
Noordam R Noordam Raymond R Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, 2333, The Netherlands.
Nyberg L Nyberg Lars L Department of Integrative Medical Biology, Umeå University, Umeå, SE-901 87, Sweden.
Ollier W Ollier William W Centre for Integrated Genomic Medical Research, Institute of Population Health, University of Manchester, Manchester, M13 9PT, UK.
Papenberg G Papenberg Goran G Karolinska Institutet, Aging Research Center, Stockholm University, Stockholm, SE-113 30, Sweden.
Pattie A Pattie Alison A Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Polasek O Polasek Ozren O Faculty of Medicine, University of Split, Split, 21000, Croatia.
Poldrack RA Poldrack Russell A RA Department of Psychology, Stanford University, Palo Alto, 94305-2130, CA, USA.
Psaty BM Psaty Bruce M BM Kaiser Permanente Washington Health Research Institute, Seattle, 98101, WA, USA.
Reppermund S Reppermund Simone S Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, 2052, Australia.
Riedel-Heller SG Riedel-Heller Steffi G SG Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, 04103, Germany.
Rose RJ Rose Richard J RJ Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405-7007, USA.
Rotter JI Rotter Jerome I JI Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90509, CA, USA.
Roussos P Roussos Panos P Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, Bronx, 10468, NY, USA.
Rovio SP Rovio Suvi P SP Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.
Saba Y Saba Yasaman Y Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8036, Austria.
Sabb FW Sabb Fred W FW Robert and Beverly Lewis Center for Neuroimaging, University of Oregon, Eugene, 97403, OR, USA.
Sachdev PS Sachdev Perminder S PS Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, 2031, Australia.
Satizabal CL Satizabal Claudia L CL The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, 01702-5827, MA, USA.
Schmid M Schmid Matthias M Department of Medical Biometry, Informatics and Epidemiology, University Hospital, Bonn, D-53012, Germany.
Scott RJ Scott Rodney J RJ Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New South Wales, 2305, Australia.
Scult MA Scult Matthew A MA Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, 27708-0086, NC, USA.
Simino J Simino Jeannette J Department of Data Science, University of Mississippi Medical Center, Jackson, 39216, MS, USA.
Slagboom PE Slagboom P Eline PE Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.
Smyrnis N Smyrnis Nikolaos N University Mental Health Research Institute, Athens, GR-156 01, Greece.
Soumaré A Soumaré Aïcha A University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000, Bordeaux, France.
Stefanis NC Stefanis Nikos C NC Neurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, 11521, Greece.
Stott DJ Stott David J DJ Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
Straub RE Straub Richard E RE Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, 21205, MD, USA.
Sundet K Sundet Kjetil K Division of Mental Health and Addiction, Oslo University Hospital, Oslo, 0315, Norway.
Taylor AM Taylor Adele M AM Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Taylor KD Taylor Kent D KD Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90509, CA, USA.
Tzoulaki I Tzoulaki Ioanna I Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece.
Tzourio C Tzourio Christophe C Department of Public Health, University Hospital of Bordeaux, Bordeaux, 33076, France.
Uitterlinden A Uitterlinden André A Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.
Vitart V Vitart Veronique V Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Voineskos AN Voineskos Aristotle N AN Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, M5T 1L8, Canada.
Kaprio J Kaprio Jaakko J Department of Public Health, University of Helsinki, Helsinki, 00014, Finland.
Wagner M Wagner Michael M Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, 53127, Germany.
Wagner H Wagner Holger H Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, 53127, Germany.
Weinhold L Weinhold Leonie L Department of Medical Biometry, Informatics and Epidemiology, University Hospital, Bonn, D-53012, Germany.
Wen KH Wen K Hoyan KH Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.
Widen E Widen Elisabeth E Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.
Yang Q Yang Qiong Q Department of Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.
Zhao W Zhao Wei W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Adams HHH Adams Hieab H H HHH Department of Radiology, Erasmus MC, Rotterdam, 3015, The Netherlands.
Arking DE Arking Dan E DE McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, 21287, USA.
Bilder RM Bilder Robert M RM UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, 90024, CA, USA.
Bitsios P Bitsios Panos P Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, GR-71003, Greece.
Boerwinkle E Boerwinkle Eric E Human Genome Sequencing Center, Baylor College of Medicine, Houston, 77030-3411, TX, USA.
Chiba-Falek O Chiba-Falek Ornit O Department of NeurologyBryan Alzheimer's Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, 27708, NC, USA.
Corvin A Corvin Aiden A Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, DO2 AY89, Ireland.
De Jager PL De Jager Philip L PL Program in Medical and Population Genetics, Broad Institute, Cambridge, 02142, MA, USA.
Debette S Debette Stéphanie S Department of Neurology, University Hospital of Bordeaux, Bordeaux, 33000, France.
Donohoe G Donohoe Gary G Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, H91 TK33, Ireland.
Elliott P Elliott Paul P MRC-PHE Centre for Environment, School of Public Health, Imperial College London, London, W2 1PG, UK.
Fitzpatrick AL Fitzpatrick Annette L AL Department of Global Health, University of Washington, Seattle, 98104, WA, USA.
Gill M Gill Michael M Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, DO2 AY89, Ireland.
Glahn DC Glahn David C DC Department of Psychiatry, Yale University School of Medicine, New Haven, 06511, CT, USA.
Hägg S Hägg Sara S Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Hansell NK Hansell Narelle K NK Queensland Brain Institute, University of Queensland, Brisbane, 4072, Australia.
Hariri AR Hariri Ahmad R AR Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, 27708-0086, NC, USA.
Ikram MK Ikram M Kamran MK Department of Neurology, Erasmus University Medical Center, Rotterdam, xxxxxx, The Netherlands.
Jukema JW Jukema J Wouter JW Department of Cardiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.
Vuoksimaa E Vuoksimaa Eero E Department of Public Health, University of Helsinki, Helsinki, 00014, Finland.
Keller MC Keller Matthew C MC Institute for Behavioral Genetics, University of Colorado, Boulder, 80309, CO, USA.
Kremen WS Kremen William S WS Center for Behavior Genetics of Aging, University of California, San Diego, 92093, CA, USA.
Launer L Launer Lenore L Intramural Research Program National Institutes on Aging, National Institutes of Health, Bethesda, 20892, MD, USA.
Lindenberger U Lindenberger Ulman U Max Planck Institute for Human Development, Berlin, 14195, Germany.
Palotie A Palotie Aarno A Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, 00014, Finland.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Pendleton N Pendleton Neil N Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Manchester Academic Health Science Centre, and Manchester Medical School, Institute of Brain, Behaviour, and Mental Health, University of Manchester, Manchester, M13 9PL, UK.
Porteous DJ Porteous David J DJ Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Räikkönen K Räikkönen Katri K Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.
Raitakari OT Raitakari Olli T OT Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20520, Finland.
Ramirez A Ramirez Alfredo A Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, 53127, Germany.
Reinvang I Reinvang Ivar I Division of Mental Health and Addiction, Oslo University Hospital, Oslo, 0315, Norway.
Rudan I Rudan Igor I Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Dan Rujescu Dan Rujescu Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, 06108, Germany.
Schmidt R Schmidt Reinhold R Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, 8036, Austria.
Schmidt H Schmidt Helena H Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8036, Austria.
Schofield PW Schofield Peter W PW School of Medicine and Public Health, University of Newcastle, New South Wales, 2308, Australia.
Schofield PR Schofield Peter R PR Faculty of Medicine, University of New South Wales, Sydney, 2052, Australia.
Starr JM Starr John M JM Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Steen VM Steen Vidar M VM Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, 5020, Norway.
Trollor JN Trollor Julian N JN Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, 2052, Australia.
Turner ST Turner Steven T ST Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
Van Duijn CM Van Duijn Cornelia M CM Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.
Villringer A Villringer Arno A Day Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig, 04103, Germany.
Weinberger DR Weinberger Daniel R DR Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, 21205, MD, USA.
Weir DR Weir David R DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
Wilson JF Wilson James F JF Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Malhotra A Malhotra Anil A Department of Psychiatry, Hofstra Northwell School of Medicine, Hempstead, 11549, NY, USA.
McIntosh AM McIntosh Andrew M AM Division of Psychiatry, University of Edinburgh, Edinburgh, EH10 5HF, UK.
Gale CR Gale Catharine R CR MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, SO16 6YD, UK.
Seshadri S Seshadri Sudha S Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, 78229, TX, USA.
Mosley TH Jr Mosley Thomas H TH Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, 39216, MS, USA.
Bressler J Bressler Jan J Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Lencz T Lencz Todd T Division of Psychiatry, University of Edinburgh, Edinburgh, EH10 5HF, UK.
Deary IJ Deary Ian J IJ Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK. i.deary@ed.ac.uk.
INVESTIGATORS
JOURNAL
VOLUME: 9
ISSUE: 1
TITLE: Nature communications
ISOABBREVIATION: Nat Commun
YEAR: 2018
MONTH: May
DAY: 29
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2041-1723
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Commun
COUNTRY: England
ISSNLINKING: 2041-1723
NLMUNIQUEID: 101528555
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 AG033193 NIA NIH HHS United States
U01 AG049505 NIA NIH HHS United States
U01 AG052409 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's