Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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29760442
TITLE
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.
ABSTRACT
) but not between CCT and primary open-angle glaucoma (r = -0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation.
DATE PUBLISHED
2018 May 14
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/06/24
accepted 2018/03/02
entrez 2018/05/16 06:00
pubmed 2018/05/16 06:00
medline 2018/05/16 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Iglesias AI Iglesias Adriana I AI Department of Clinical Genetics, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.
Mishra A Mishra Aniket A University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000, Bordeaux, France.
Vitart V Vitart Veronique V Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, EH42XU, Edinburgh, UK.
Bykhovskaya Y Bykhovskaya Yelena Y Cornea Genetic Eye Institute, CA 90048, Los Angeles, CA, USA.
Höhn R Höhn René R Department of Ophthalmology, Inselspital, University Hospital Bern, University of Bern, Bern, CH-3010, Switzerland.
Springelkamp H Springelkamp Henriët H Department of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.
Cuellar-Partida G Cuellar-Partida Gabriel G Statistical Genetics, QIMR Berghofer Medical Research Institute, QLD 4029, Brisbane, Australia.
Gharahkhani P Gharahkhani Puya P Statistical Genetics, QIMR Berghofer Medical Research Institute, QLD 4029, Brisbane, Australia.
Bailey JNC Bailey Jessica N Cooke JNC Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Willoughby CE Willoughby Colin E CE Royal Victoria Hospital, Belfast Health and Social Care Trust, BT12 6BA, Belfast, Northern Ireland, UK.
Li X Li Xiaohui X Division of Genomic Outcomes, Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, CA, USA.
Yazar S Yazar Seyhan S Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, WA 6009, Perth, WA, Australia.
Nag A Nag Abhishek A Department of Twin Research and Genetic Epidemiology, King's College London, WC2R 2LS, London, UK.
Khawaja AP Khawaja Anthony P AP NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, EC1V 9EL, London, UK.
Polašek O Polašek Ozren O Faculty of Medicine, University of Split, HR-21000, Split, Croatia.
Siscovick D Siscovick David D The New York Academy of Medicine, NY 10029, New York, NY, USA.
Mitchell P Mitchell Paul P Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, NSW 2145, Sydney, NSW, Australia.
Tham YC Tham Yih Chung YC Singapore Eye Research Institute, Singapore National Eye Centre, 168751, Singapore, Singapore.
Haines JL Haines Jonathan L JL Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Kearns LS Kearns Lisa S LS Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, VIC 3002, East Melbourne, Australia.
Hayward C Hayward Caroline C Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, EH42XU, Edinburgh, UK.
Shi Y Shi Yuan Y Singapore Eye Research Institute, Singapore National Eye Centre, 168751, Singapore, Singapore.
van Leeuwen EM van Leeuwen Elisabeth M EM Department of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.
Taylor KD Taylor Kent D KD Division of Genomic Outcomes, Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, CA, USA.
Blue Mountains Eye Study—GWAS group
Bonnemaijer P Bonnemaijer Pieter P Department of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.
Rotter JI Rotter Jerome I JI Division of Genomic Outcomes, Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, CA, USA.
Martin NG Martin Nicholas G NG Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, QLD 4029, Brisbane, Australia.
Zeller T Zeller Tanja T German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246, Hamburg, Germany.
Mills RA Mills Richard A RA Department of Ophthalmology, Flinders University, SA 5042, Adelaide, Australia.
Staffieri SE Staffieri Sandra E SE Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, VIC 3002, East Melbourne, Australia.
Jonas JB Jonas Jost B JB Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, 68167, Mannheim, Germany.
Schmidtmann I Schmidtmann Irene I Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, 55131, Mainz, Germany.
Boutin T Boutin Thibaud T Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, EH42XU, Edinburgh, UK.
Kang JH Kang Jae H JH Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, MA, USA.
Lucas SEM Lucas Sionne E M SEM Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7005, TAS, Australia.
Wong TY Wong Tien Yin TY Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117549, Singapore.
Beutel ME Beutel Manfred E ME Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Mainz, 55131, Germany.
Wilson JF Wilson James F JF Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, EH16 4UX, Edinburgh, UK.
NEIGHBORHOOD Consortium
Wellcome Trust Case Control Consortium 2 (WTCCC2)
Uitterlinden AG Uitterlinden André G AG Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, 2593 HW, The Hague, The Netherlands.
Vithana EN Vithana Eranga N EN Singapore Eye Research Institute, Singapore National Eye Centre, 168751, Singapore, Singapore.
Foster PJ Foster Paul J PJ NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, EC1V 9EL, London, UK.
Hysi PG Hysi Pirro G PG Department of Twin Research and Genetic Epidemiology, King's College London, WC2R 2LS, London, UK.
Hewitt AW Hewitt Alex W AW School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7005, TAS, Australia.
Khor CC Khor Chiea Chuen CC Genome Institute of Singapore, 60 Biopolis Street, Singapore, 138672, Singapore.
Pasquale LR Pasquale Louis R LR Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA 02114, MA, USA.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, University of Queensland, QLD 4067, Brisbane, Australia.
Klaver CCW Klaver Caroline C W CCW Department of Ophthalmology, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Aung T Aung Tin T Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117549, Singapore.
Pfeiffer N Pfeiffer Norbert N Department of Ophthalmology, University Medical Center Mainz, 55131, Mainz, Germany.
Mackey DA Mackey David A DA Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, WA 6009, Perth, WA, Australia.
Hammond CJ Hammond Christopher J CJ Department of Twin Research and Genetic Epidemiology, King's College London, WC2R 2LS, London, UK.
Cheng CY Cheng Ching-Yu CY Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117549, Singapore.
Craig JE Craig Jamie E JE Department of Ophthalmology, Flinders University, SA 5042, Adelaide, Australia.
Rabinowitz YS Rabinowitz Yaron S YS Cornea Genetic Eye Institute, CA 90048, Los Angeles, CA, USA.
Wiggs JL Wiggs Janey L JL Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA 02114, MA, USA.
Burdon KP Burdon Kathryn P KP Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7005, TAS, Australia.
van Duijn CM van Duijn Cornelia M CM Department of Epidemiology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.
MacGregor S MacGregor Stuart S Statistical Genetics, QIMR Berghofer Medical Research Institute, QLD 4029, Brisbane, Australia. Stuart.MacGregor@qimrberghofer.edu.au.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Wang Jie Jin JJ
Rochtchina Elena E
Attia John J
Scott Rodney R
Holliday Elizabeth G EG
Wong Tien Yin TY
Baird Paul N PN
Xie Jing J
Inouye Michael M
Viswanathan Ananth A
Sim Xueling X
Allingham R Rand RR
Brilliant Murray H MH
Budenz Donald L DL
Christen William G WG
Fingert John J
Friedman David S DS
Gaasterland Douglas D
Gaasterland Terry T
Hauser Michael A MA
Kraft Peter P
Lee Richard K RK
Lichter Paul R PR
Liu Yutao Y
Loomis Stephanie J SJ
Moroi Sayoko E SE
Pericak-Vance Margaret A MA
Realini Anthony A
Richards Julia E JE
Schuman Joel S JS
Scott William K WK
Singh Kuldev K
Sit Arthur J AJ
Vollrath Douglas D
Weinreb Robert N RN
Wollstein Gadi G
Zack Donald J DJ
Zhang Kang K
Donnelly Peter P
Barroso Ines I
Blackwell Jenefer M JM
Bramon Elvira E
Brown Matthew A MA
Casas Juan P JP
Corvin Aiden A
Deloukas Panos P
Duncanson Audrey A
Jankowski Janusz J
Markus Hugh S HS
Mathew Christopher G CG
Palmer Colin N A CNA
Plomin Robert R
Rautanen Anna A
Sawcer Stephen J SJ
Trembath Richard C RC
Wood Nicholas W NW
Spencer Chris C A CCA
Band Gavin G
Bellenguez Céline C
Freeman Colin C
Hellenthal Garrett G
Giannoulatou Eleni E
Pirinen Matti M
Pearson Richard R
Strange Amy A
Su Zhan Z
Vukcevic Damjan D
Langford Cordelia C
Hunt Sarah E SE
Edkins Sarah S
Gwilliam Rhian R
Blackburn Hannah H
Bumpstead Suzannah J SJ
Dronov Serge S
Gillman Matthew M
Gray Emma E
Hammond Naomi N
Jayakumar Alagurevathi A
McCann Owen T OT
Liddle Jennifer J
Potter Simon C SC
Ravindrarajah Radhi R
Ricketts Michelle M
Waller Matthew M
Weston Paul P
Widaa Sara S
Whittaker Pamela P
JOURNAL
VOLUME: 9
ISSUE: 1
TITLE: Nature communications
ISOABBREVIATION: Nat Commun
YEAR: 2018
MONTH: May
DAY: 14
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2041-1723
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Commun
COUNTRY: England
ISSNLINKING: 2041-1723
NLMUNIQUEID: 101528555
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Journal Article
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