Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
29743129
TITLE
Establishing a Twin Register: An Invaluable Resource for (Behavior) Genetic, Epidemiological, Biomarker, and 'Omics' Studies.
ABSTRACT
Twin registers are wonderful research resources for research applications in medical and behavioral genetics, epidemiology, psychology, molecular genetics, and other areas of research. New registers continue to be launched all over the world as researchers from different disciplines recognize the potential to boost and widen their research agenda. In this article, we discuss multiple aspects that need to be taken into account when initiating a register, from its preliminary sketch to its actual development. This encompasses aspects related to the strategic planning and key elements of research designs, promotion and management of a twin register, including recruitment and retaining of twins and family members of twins, phenotyping, database organization, and collaborations between registers. We also present information on questions unique to twin registers and twin-biobanks, such as the assessment of zygosity by SNP arrays, the design of (biomarker) studies involving related participants, and the analyses of clustered data. Altogether, we provide a number of basic guidelines and recommendations for reflection when planning a twin register.
DATE PUBLISHED
2018 May 10
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2018/05/11 06:00
pubmed 2018/05/11 06:00
medline 2018/05/11 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Odintsova VV Odintsova Veronika V VV Netherlands Twin Register,Department of Biological Psychology,Vrije Universiteit Amsterdam, andAmsterdam Public Health (APH),Amsterdam,the Netherlands.
Willemsen G Willemsen Gonneke G Netherlands Twin Register,Department of Biological Psychology,Vrije Universiteit Amsterdam, andAmsterdam Public Health (APH),Amsterdam,the Netherlands.
Dolan CV Dolan Conor V CV Netherlands Twin Register,Department of Biological Psychology,Vrije Universiteit Amsterdam, andAmsterdam Public Health (APH),Amsterdam,the Netherlands.
Hottenga JJ Hottenga Jouke-Jan JJ Netherlands Twin Register,Department of Biological Psychology,Vrije Universiteit Amsterdam, andAmsterdam Public Health (APH),Amsterdam,the Netherlands.
Martin NG Martin Nicholas G NG Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Australia.
Slagboom PE Slagboom P Eline PE Department of Molecular Epidemiology,Leiden University Medical Centre,Leiden,the Netherlands.
Ordoñana JR Ordoñana Juan R JR Department of Human Anatomy and Psychobiology,University of Murcia, andMurcia Institute for BioHealth Research (IMIB-Arrixaca-UMU),Murcia,Spain.
Boomsma DI Boomsma Dorret I DI Netherlands Twin Register,Department of Biological Psychology,Vrije Universiteit Amsterdam, andAmsterdam Public Health (APH),Amsterdam,the Netherlands.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2018
MONTH: May
DAY: 10
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
recruitment
twin register
twin research
zygosity determination
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's