Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
29692273
TITLE
Extended Twin Study of Alcohol Use in Virginia and Australia.
ABSTRACT
Drinking alcohol is a normal behavior in many societies, and prior studies have demonstrated it has both genetic and environmental sources of variation. Using two very large samples of twins and their first-degree relatives (Australia ≈ 20,000 individuals from 8,019 families; Virginia ≈ 23,000 from 6,042 families), we examine whether there are differences: (1) in the genetic and environmental factors that influence four interrelated drinking behaviors (quantity, frequency, age of initiation, and number of drinks in the last week), (2) between the twin-only design and the extended twin design, and (3) the Australian and Virginia samples. We find that while drinking behaviors are interrelated, there are substantial differences in the genetic and environmental architectures across phenotypes. Specifically, drinking quantity, frequency, and number of drinks in the past week have large broad genetic variance components, and smaller but significant environmental variance components, while age of onset is driven exclusively by environmental factors. Further, the twin-only design and the extended twin design come to similar conclusions regarding broad-sense heritability and environmental transmission, but the extended twin models provide a more nuanced perspective. Finally, we find a high level of similarity between the Australian and Virginian samples, especially for the genetic factors. The observed differences, when present, tend to be at the environmental level. Implications for the extended twin model and future directions are discussed.
DATE PUBLISHED
2018 Apr 25
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2018/04/26 06:00
pubmed 2018/04/26 06:00
medline 2018/04/26 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Verhulst B Verhulst Brad B Department of Psychology,Michigan State University,East Lansing,MI,USA.
Neale MC Neale Michael C MC Department of Psychiatry and Department of Human Genetics,Virginia Commonwealth University,Richmond,VA,USA.
Eaves LJ Eaves Lindon J LJ Department of Psychiatry and Department of Human Genetics,Virginia Commonwealth University,Richmond,VA,USA.
Medland SE Medland Sarah E SE Department of Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Royal Brisbane Hospital,Brisbane,Australia.
Heath AC Heath Andrew C AC Department of Psychiatry Washington University,St. Louis,MO,USA.
Martin NG Martin Nicholas G NG Department of Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Royal Brisbane Hospital,Brisbane,Australia.
Maes HH Maes Hermine H HH Department of Psychiatry and Department of Human Genetics,Virginia Commonwealth University,Richmond,VA,USA.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2018
MONTH: Apr
DAY: 25
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
age of drinking onset
broad-sense heritability
drinking frequency
drinking quantity
extended twin model
number of drinks in the last week
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's