Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
29659830
TITLE
Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero.
ABSTRACT
The ratio of the length of the index finger to that of the ring finger (2D:4D) is sexually dimorphic and is commonly used as a noninvasive biomarker of prenatal androgen exposure. Most association studies of 2D:4D ratio with a diverse range of sex-specific traits have typically involved small sample sizes and have been difficult to replicate, raising questions around the utility and precise meaning of the measure. In the largest genome-wide association meta-analysis of 2D:4D ratio to date (N = 15,661, with replication N = 75,821), we identified eleven loci (nine novel) explaining 3.8% of the variance in mean 2D:4D ratio. We also found weak evidence for association (β = 0.06; P = 0.02) between 2D:4D ratio and sensitivity to testosterone (length of the CAG microsatellite repeat in the androgen receptor gene) in females only. Furthermore, genetic variants associated with (adult) testosterone levels and/or sex hormone-binding globulin were not associated with 2D:4D ratio in our sample. Although we were unable to find strong evidence from our genetic study to support the hypothesis that 2D:4D ratio is a direct biomarker of prenatal exposure to androgens in healthy individuals, our findings do not explicitly exclude this possibility, and pathways involving testosterone may become apparent as the size of the discovery sample increases further. Our findings provide new insight into the underlying biology shaping 2D:4D variation in the general population.
DATE PUBLISHED
2018 Apr 12
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2017/11/05
accepted 2018/04/03
entrez 2018/04/17 06:00
pubmed 2018/04/17 06:00
medline 2018/04/17 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Warrington NM Warrington Nicole M NM Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, 6009, Australia.
Shevroja E Shevroja Enisa E Department of Internal Medicine, Erasmus Medical Center, 3015, Rotterdam, The Netherlands.
Hemani G Hemani Gibran G Population Health Sciences, University of Bristol, Bristol, BS8 2PS, England.
Hysi PG Hysi Pirro G PG Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, England.
Jiang Y Jiang Yunxuan Y 23andMe, Inc., Mountain View, CA, 94061, USA.
Auton A Auton Adam A 23andMe, Inc., Mountain View, CA, 94061, USA.
Boer CG Boer Cindy G CG Department of Internal Medicine, Erasmus Medical Center, 3015, Rotterdam, The Netherlands.
Mangino M Mangino Massimo M Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, England.
Wang CA Wang Carol A CA Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, 6009, Australia.
Kemp JP Kemp John P JP Population Health Sciences, University of Bristol, Bristol, BS8 2PS, England.
McMahon G McMahon George G Population Health Sciences, University of Bristol, Bristol, BS8 2PS, England.
Medina-Gomez C Medina-Gomez Carolina C Department of Epidemiology, Erasmus Medical Center, 3015, Rotterdam, Netherlands.
Hickey M Hickey Martha M Department of Obstetrics and Gynaecology, The University of Melbourne and the Royal Women's Hospital, Parkville, Victoria, 3052, Australia.
Trajanoska K Trajanoska Katerina K Department of Epidemiology, Erasmus Medical Center, 3015, Rotterdam, Netherlands.
Wolke D Wolke Dieter D Department of Psychology and Warwick Medical School, University of Warwick, Coventry CV47AL, England.
Ikram AM Ikram Arfan M AM Department of Epidemiology, Erasmus Medical Center, 3015, Rotterdam, Netherlands.
23 and Me Research Team
Montgomery GW Montgomery Grant W GW Queensland Brain Institute and Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, 4062, Australia.
Felix JF Felix Janine F JF Department of Pediatrics, Erasmus Medical Center, 3015, Rotterdam, The Netherlands.
Wright MJ Wright Margaret J MJ Queensland Brain Institute and Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, 4062, Australia.
Mackey DA Mackey David A DA Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, 6009, Australia.
Jaddoe VW Jaddoe Vincent W VW Department of Pediatrics, Erasmus Medical Center, 3015, Rotterdam, The Netherlands.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research, Brisbane, Queensland, 4006, Australia.
Tung JY Tung Joyce Y JY 23andMe, Inc., Mountain View, CA, 94061, USA.
Davey Smith G Davey Smith George G Population Health Sciences, University of Bristol, Bristol, BS8 2PS, England.
Pennell CE Pennell Craig E CE Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, 6009, Australia.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, England.
van Meurs J van Meurs Joyce J The Generation R Study Group, Erasmus Medical Center, 3015, Rotterdam, The Netherlands.
Rivadeneira F Rivadeneira Fernando F Department of Epidemiology, Erasmus Medical Center, 3015, Rotterdam, Netherlands.
Medland SE Medland Sarah E SE Queensland Institute of Medical Research, Brisbane, Queensland, 4006, Australia.
Evans DM Evans David M DM Population Health Sciences, University of Bristol, Bristol, BS8 2PS, England.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Human molecular genetics
ISOABBREVIATION: Hum. Mol. Genet.
YEAR: 2018
MONTH: Apr
DAY: 12
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1460-2083
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hum Mol Genet
COUNTRY: England
ISSNLINKING: 0964-6906
NLMUNIQUEID: 9208958
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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