Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
29530110
TITLE
Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis: trivariate twin modelling and implications for genetic design.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
The genetic component of Cannabis Use Disorder may overlap with influences acting more generally on early stages of cannabis use. This paper aims to determine the extent to which genetic influences on the development of cannabis abuse/dependence are correlated with those acting on the opportunity to use cannabis and frequency of use.
METHODS NlmCategory: METHODS
A cross-sectional study of 3303 Australian twins, measuring age of onset of cannabis use opportunity, lifetime frequency of cannabis use, and lifetime DSM-IV cannabis abuse/dependence. A trivariate Cholesky decomposition estimated additive genetic (A), shared environment (C) and unique environment (E) contributions to the opportunity to use cannabis, the frequency of cannabis use, cannabis abuse/dependence, and the extent of overlap between genetic and environmental factors associated with each phenotype.
RESULTS NlmCategory: RESULTS
Variance components estimates were A = 0.64 [95% confidence interval (CI) 0.58-0.70] and E = 0.36 (95% CI 0.29-0.42) for age of opportunity to use cannabis, A = 0.74 (95% CI 0.66-0.80) and E = 0.26 (95% CI 0.20-0.34) for cannabis use frequency, and A = 0.78 (95% CI 0.65-0.88) and E = 0.22 (95% CI 0.12-0.35) for cannabis abuse/dependence. Opportunity shares 45% of genetic influences with the frequency of use, and only 17% of additive genetic influences are unique to abuse/dependence from those acting on opportunity and frequency.
CONCLUSIONS NlmCategory: CONCLUSIONS
There are significant genetic contributions to lifetime cannabis abuse/dependence, but a large proportion of this overlaps with influences acting on opportunity and frequency of use. Individuals without drug use opportunity are uninformative, and studies of drug use disorders must incorporate individual exposure to accurately identify aetiology.
DATE PUBLISHED
2018 Mar 13
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2018/03/14 06:00
pubmed 2018/03/14 06:00
medline 2018/03/14 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hines LA Hines Lindsey A LA Addictions Department,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London,England.
Morley KI Morley Katherine I KI Addictions Department,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London,England.
Rijsdijk F Rijsdijk Fruhling F Social Genetic and Developmental Psychiatry Centre,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London,England.
Strang J Strang John J Addictions Department,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London,England.
Agrawal A Agrawal Arpana A Department of Psychiatry,Washington University School of Medicine,St Louis,MO,USA.
Nelson EC Nelson Elliot C EC Department of Psychiatry,Washington University School of Medicine,St Louis,MO,USA.
Statham D Statham Dixie D School of Social Sciences,University of the Sunshine Coast,Queensland,Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Lynskey MT Lynskey Michael T MT Addictions Department,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London,England.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 2018
MONTH: Mar
DAY: 13
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1469-8978
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Abuse
addiction
behavioural genetics
cannabis
dependence
frequency
opportunity
twins
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's